mechanism 1,970 words KG: ent-gene-9f063e98
Contents

LRRK2 Signaling Pathway in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-9f063e98
LRR DomainLeucine-rich repeat region at the N-terminus, involved in protein-protein interactions
ROC DomainRas of complex (ROC) GTPase domain that binds and hydrolyzes GTP
COR DomainC-terminal of ROC, links GTPase and kinase activities
Kinase DomainSerine/Threonine protein kinase domain (the therapeutic target)
WD40 RepeatC-terminal WD40 repeat involved in substrate recognition
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (58)

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TREM2-Mediated Selective Aggregate Clearance Pathway
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Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
APOE-Dependent Autophagy Restoration
Score: 0.89
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
← Prevpg 3/3

Related Analyses (30)

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Related Experiments (30)

Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40
Prodromal Parkinson's Disease Biomarker Development — Early
clinical · proposed · Score: 0.40
Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

40690364 counteracts ent-gene-9f063e98
40690364 phosphorylates ent-gene-9f063e98
38307024 phosphorylates and inactivates ent-gene-9f063e98
33177079 is recruited to ent-gene-9f063e98
33177079 recruits ent-gene-9f063e98
33177079 recruits JIP4 to lysosomes via phosphorylation of ent-gene-9f063e98
33177079 is orchestrated by ent-gene-9f063e98
32853409 phosphorylates ent-gene-9f063e98
34125248 is an endogenous substrate of ent-gene-9f063e98
38307024 phosphorylates ent-gene-9f063e98

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