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mechanism 1,874 words KG: proteasome 2026-03-24
kind:mechanismsection:mechanismsstate:published
Contents

Proteasome Dysfunction in Progressive Supranuclear Palsy

⚙ Mechanism Info
NameProteasome Dysfunction in Progressive Supranuclear Palsy
SummaryPage for Proteasome Dysfunction in Progressive Supranuclear Palsy
Key Genes/ProteinsTNF, UBIQUITIN, TTP, α-synuclein
Related DiseasesTNF-α mRNA stability
Linked Hypotheses1 hypotheses

Knowledge Graph

Related Hypotheses (30)

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Score: 0.41ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66Circadian-Gated Maresin Biosynthesis Amplification
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Score: 0.68Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (30)

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Related Experiments (28)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
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falsification · proposed · Score: 0.40Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activatesACTB Gene
gene · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: regulatesABCD3 Gene
gene · KG edge: therapeutic_targetABCD2 — ATP Binding Cassette Subfamily D Member 2
gene · KG edge: therapeutic_target

Knowledge Graph (5 edges)

proteasome regulates TNF-α mRNA stability
proteasome regulates TNF
proteasome modifies TTP
α-synuclein interacts_with proteasome
UBIQUITIN binds_to proteasome
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