gene 670 words KG: ABCD3 2026-03-12
kind:genesection:genesstate:published
Contents

ABCD3 Gene

🧬 Gene Info
Gene SymbolABCD3
Full NameATP-Binding Cassette Subfamily D Member 3
Chromosome1p22.1
Protein FamilyABC transporter subfamily D
Protein TypeTransporter
FunctionABCD3 functions as a peroxisomal membrane transporter
Primary Expressionmultiple tissues, with highest levels in liver, kidney, and brain
Subcellular LocalizationPeroxisomal membrane
Molecular Weight~79 kDa
PathwaysTgf-Beta, Wnt
UniProt ID[O75323](https://www.uniprot.org/uniprot/O75323)
GeneCardsABCD3
Human Protein AtlasABCD3
LocationChromosome 1p22.1
Protein ClassABC transporter (peroxisomal)
Associated DiseasesAD, ALI, ALS, Alzheimer, Cancer
InteractionsFIP200, RTN3, SESN2, LMNA, MAP1LC3B, OPTN
KG Connections474 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

ABCD3 interacts_with FIP200
ABCD3 interacts_with RTN3
ABCD3 interacts_with SESN2
ABCD3 interacts_with LMNA
ABCD3 interacts_with MAP1LC3B
ABCD3 interacts_with OPTN
ABCD3 interacts_with AMBRA1
ABCD3 interacts_with CTSD
ABCD3 interacts_with MUL1
ABCD3 interacts_with PARKIN