| Gene Symbol | ent-gene-677b2317 |
| Subcellular Localization | the endoplasmic reticulum (ER) membrane, particularly at the ER-mitochondria interface (MAMs - mitochondrial-associated |
| PRE-084 | A highly selective sigma-1 receptor agonist that has demonstrated neuroprotective effects in multiple models of neurodegeneration [@pre] |
| SA-4503 (Cutamesine) | Showed promise in clinical trials for stroke recovery and has been investigated for neurodegenerative diseases [@cutamesine] |
| Dextromethorphan | A commonly used antitussive that also possesses sigma-1 agonist activity |
| Donepezil | An approved acetylcholinesterase inhibitor for Alzheimer's disease that also acts as a sigma-1 agonist [@donepezil] |
| Fluvoxamine | An SSRI antidepressant with sigma-1 agonist properties [@fluvoxamine] |
| Haloperidol | A typical antipsychotic with sigma-1 antagonist activity |
| BD1063 | A selective sigma-1 antagonist used in research |
| NE-100 | A potent and selective sigma-1 antagonist |
| ER Calcium Homeostasis | Sigma-1 regulates calcium release through IP3Rs and ryanodine receptors, preventing pathological calcium depletion from ER stores |
| Mitochondrial Calcium Uptake | By modulating VDACs and the mitochondrial calcium uniporter (MCU), sigma-1 controls mitochondrial calcium levels essential for ATP production |
| Calcium Buffering | In neurons, proper mitochondrial calcium buffering is crucial for synaptic function and survival |
| Store-Operated Calcium Entry | Sigma-1 modulates STIM1 and Orai1 function, affecting store-operated calcium entry mechanisms |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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