mechanism 2,969 words KG: ent-gene-a6bc93bc 2026-03-24
kind:mechanismsection:mechanismsstate:published
Contents

TNF Signaling Pathway in Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-a6bc93bc
Pro-inflammatory cytokinesIL-1β, IL-6, IL-8
ChemokinesCCL2, CXCL10
Acute phase proteinsC-reactive protein, serum amyloid A
Anti-apoptotic proteinsBcl-2, Bcl-xL, c-IAP1/2
Cell adhesion moleculesICAM-1, VCAM-1
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S
Score: 0.55
Astrocyte-Microglia Communication Rebalancing via Cytokine M
Score: 0.49
Cardiovascular-Neuroinflammatory Dual Targeting
Score: 0.46
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (30)

Systemic immune profiling and peripheral immune contribution
neurodegeneration · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Why do systemic anti-inflammatory drugs fail in AD despite c
clinical neurology · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (30)

Electroacupuncture ST37 treatment for DSS-induced colitis in
validation · proposed · Score: 0.95
Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
Acteoside treatment in LPS-induced SALI mouse model
validation · proposed · Score: 0.90
In vitro PANoptosis protection by LPT1 in hepatocytes
exploratory · proposed · Score: 0.80
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (2 edges)

ent-gene-a6bc93bc data_in benchmark_ot_ad_answer_key:TNF
benchmark_ot_ad_answer_key:TNF data_in ent-gene-a6bc93bc