| Gene Symbol | PI3K (family), PIK3CA, PIK3CB, etc. |
| Full Name | Phosphoinositide 3-Kinase |
| Aliases | PI3K, Phosphatidylinositol 3-kinase, VPS34 |
| Chromosome | Various (multiple genes across classes) |
| Protein Type | Kinase |
| Function | Class I PI3Ks: Generate PIP3 from PIP2 - Activated by receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), and small GTPases (Ras) - p110α (PIK3CA): growth factor signaling |
| Pathways | AUTOPHAGY, LIPID METABOLISM, OXIDATIVE_STRESS, PI3K/AKT, PI3K_AKT_MTOR_pathway |
| NCBI Gene ID | Multiple (e.g., PIK3CA: 5290, PIK3CB: 5293) |
| Protein | Phosphoinositide 3-kinase |
| Strategy | Development Stage |
| mTOR inhibitors (rapamycin) | Preclinical/Clinical |
| Akt activators | Preclinical |
| GSK3β inhibitors | Clinical trials |
| PI3K isoform-selective | Preclinical |
| PTEN | Opposing enzyme |
| Associated Diseases | AD, ALS, AMI, ARM, Aging |
| Known Drugs/Compounds | CAMP, RAPAMYCIN, QUERCETIN, RESVERATROL, Rehmannioside_A, LY294002 |
| Interactions | LOX, MTOR, AKT, SQSTM1, EIF4EBP1, P62 |
| KG Connections | 5220 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |