| Gene Symbol | PI3K |
| Full Name | Phosphoinositide 3-Kinase |
| Aliases | Phosphatidylinositol 3-kinase, VPS34 |
| Chromosome | Various (multiple genes across classes) |
| Protein Type | Kinase |
| Function | Class I PI3Ks: Generate PIP3 from PIP2 - Activated by receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), and small GTPases (Ras) - p110α (PIK3CA): growth factor signaling |
| Pathways | AUTOPHAGY, LIPID METABOLISM, OXIDATIVE_STRESS, PI3K/AKT, PI3K_AKT_MTOR_pathway |
| NCBI Gene ID | 5290 |
| GeneCards | PI3K |
| Human Protein Atlas | PI3K |
| Associated Diseases | AD, aging, Als, Alzheimer |
| Known Drugs/Compounds | AFB1, alpelisib, Apitolisib, BERBERINE, CAMP, carvone |
| Interactions | 6-OHDA, ABCA1, ABCG1, ACAT1, ACHE, ACLY |
| KG Connections | 4911 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!