concept

AMI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

30Hypotheses

0Analyses

0Outgoing

50Incoming

11Experiments

0Debates

Summary

AMI is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AMI
Key Genes/Proteins	A2M, ABCA1, ABCG1, ACTB, AKT, ALS

Pathway Diagram

graph TD
    AMI["AMI"]
    MAP1B["MAP1B"] -->|"implicated in"| AMI
    MAP2["MAP2"] -->|"implicated in"| AMI
    MAP6["MAP6"] -->|"implicated in"| AMI
    RAB7A["RAB7A"] -->|"implicated in"| AMI
    LRP2["LRP2"] -->|"implicated in"| AMI
    ACTB["ACTB"] -->|"implicated in"| AMI
    CTSD["CTSD"] -->|"implicated in"| AMI
    ATG["ATG"] -->|"implicated in"| AMI
    EGFR["EGFR"] -->|"implicated in"| AMI
    SREBF1["SREBF1"] -->|"implicated in"| AMI

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (114)

Source	Relation	Type	Str
MMP9	associated_with	protein	0.72
41484454	has neuroprotective effects through	paper	0.60
HSPA1A	implicated_in	gene	0.50
ERK1	implicated_in	gene	0.50
ERK	implicated_in	gene	0.50
JNK	implicated_in	gene	0.50
PRMT1	implicated_in	gene	0.50
PHGDH	implicated_in	gene	0.50
FASN	implicated_in	gene	0.50
G3BP1	implicated_in	gene	0.50
ALS	implicated_in	gene	0.50
TOLLIP	implicated_in	gene	0.50
RASA1	implicated_in	gene	0.50
FUS	implicated_in	gene	0.50
TRIM21	implicated_in	gene	0.50
OPTN	implicated_in	gene	0.50
NDP52	implicated_in	gene	0.50
BECN1	implicated_in	gene	0.50
TAX1BP1	implicated_in	gene	0.50
GFP	implicated_in	gene	0.50
SMCR8	implicated_in	gene	0.50
VCP	implicated_in	gene	0.50
NBR1	implicated_in	gene	0.50
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
RAB7A	implicated_in	gene	0.50
LRP2	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
CTSD	implicated_in	gene	0.50
ATG	implicated_in	gene	0.50
EGFR	implicated_in	gene	0.50
SREBF1	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
MTORC1	implicated_in	gene	0.50
PPARG	implicated_in	gene	0.50
RPS6KB1	implicated_in	gene	0.50
PPARA	implicated_in	gene	0.50
LAMP1	implicated_in	gene	0.50
RUBCN	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
RAS	implicated_in	gene	0.50
RPS6	implicated_in	gene	0.50
PIK3C3	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
CAT	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.801	neuroimmunology	TREM2 in Alzheimer's Disease: Mechanisms
Lysosomal GBA1 Enhancement via Glucosylceramide Reduction	0.800	neurodegeneration	Test
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi	0.783	neurodegeneration	-

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.751	neuroscience	Circuit-level neural dynamics in neurode
Tau/MAP6 ratio as a master switch for microtubule dynamics p	0.750	neurodegeneration	-
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9	0.750	neurodegeneration	-
SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct	0.732	neurodegeneration	How do sphingomyelin/ceramide ratios spe
KCNQ2/3 (M-current) Channel Restoration Reactivates Theta Os	0.725	alzheimers	Closed-loop optogenetic targeting PV int
TDP-43 condensation thermodynamics as a therapeutic target a	0.724	neuroscience	How can subcellular compartmentalization
Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic	0.700	neurodegeneration	How do disease-associated mutations in G
Glucosylceramide Accumulation from GCase Deficiency Disrupts	0.700	neurodegeneration	-
CD8+ T-Cell Perforin Pathway as Driver of Neuronal Pyramid L	0.699	alzheimers-disease-parkinsons	-
Lysosomal Positioning Dynamics Modulation	0.686	neurodegeneration	Autophagy-lysosome pathway convergence a
Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neu	0.680	neurodegeneration	What are the mechanisms by which gut mic
Cortical Layer 5 Pyramidal Neuron GluN2B-Mediated Hyperactiv	0.679	neuroscience	GluN2B-Mediated Thalamocortical Control
Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification	0.677	translational-neuroscience	Which metabolic biomarkers can distingui
Lipid Droplet Dynamics as Phenotype Switches	0.666	neurodegeneration	Astrocyte reactivity subtypes in neurode
Chronic ISR Activation Represses Axonal Protein Synthesis in	0.650	parkinsons	-
Transglutaminase-2 Cross-Linking Inhibition Strategy	0.639	neurodegeneration	Protein aggregation cross-seeding across
Thalamic Reticular Nucleus (TRN) GluN2B Hyperexcitability Di	0.633	neuroscience	GluN2B-Mediated Thalamocortical Control
Palmitoylethanolamide-Based Endocannabinoid Therapy	0.633	-	Blood-brain barrier tight junction disru
VEGF-family genetic control of vascular-neuronal coupling in	0.626	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopa	0.618	neurodegeneration	What molecular mechanisms underlie Atrem
Cell-state stratification is required to resolve VEGF Family	0.612	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.606	neurodegeneration	What are the mechanisms by which gut mic
Glycosaminoglycan Template Disruption Approach	0.597	neurodegeneration	Protein aggregation cross-seeding across
Closed-Loop Phase-Specific Targeting of PV-to-Pyramidal Syna	0.585	alzheimers	Closed-loop optogenetic targeting PV int

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plasma ATN biomarkers across AD continuum in Chilean cohort	clinical	Alzheimer's disease	0.950	0.00	Chilean older adults (n=318) w	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	0.00	primary rodent neuronal cultur	proposed	N/A
Differential GWAS of schizophrenia vs PTSD	exploratory	schizophrenia, post-traumatic	0.900	0.00	human patients - European ance	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	0.00	primary rodent neuronal cultur	proposed	N/A
Creation and validation of 3xAD-ChAT-Cre mouse model	validation	Alzheimer's disease	0.900	0.00	3xAD-ChAT-Cre transgenic mice	proposed	N/A
GTEx brain tissue expression analysis of MAPT/CRHR1 locus	exploratory	schizophrenia, post-traumatic	0.850	0.00	human brain tissue samples fro	proposed	N/A
Microtubule domain analysis in adult axons	exploratory		0.800	0.00	adult rodent axons	proposed	N/A
Tau depletion effects on microtubule domains in adult axons	exploratory		0.800	0.00	adult rodent neurons	proposed	N/A
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat	in_vivo	post-cardiac-arrest neurodegen	0.768	0.72	Sprague-Dawley rat asphyxial c	abandoned	$48,000

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468]	["Hsu-Heng Lin", "Hui-An Chen", "Shyh-Je	Molecular genetics & genom	2026
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198]	["Aron Park", "Baeki E Kang", "Eun-Ju Ji	Genes & genomics	2026
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606]	Yu X MD, Lei J MSc, Du X MSc, He Y MSc,	Int J Surg	2026
Plasma metabolites may inhibit childhood obesity by regulating ferroptosis throu [PMID:41249848]	Wang JG, Pan XH, Li Y	Int J Obes (Lond)	2026
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198]	Park A, Kang BE, Jin EJ, Kim HJ, Lee CW	Genes Genomics	2026
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160]	Jia J, Gan Y, Li J, Li L, Meng H et al.	Adv Sci (Weinh)	2026
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468]	Lin HH, Chen HA, Lin SJ, Hsu RH, Lee NC	Mol Genet Genomic Med	2026
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160]	Jia J, Gan Y, Li J, Li L, Meng H, Sun M,	Advanced science (Weinheim, Ba	2026
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606]	Yu X, Lei J, Du X, He Y, Peng W, Yang R,	International journal of surge	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and demyelination in multiple sclerosis. [PMID:38889714]	Garton T, Gadani SP, Gill AJ, Calabresi	Neuron	2024
STING orchestrates the neuronal inflammatory stress response in multiple scleros [PMID:38878778]	Woo MS, Mayer C, Binkle-Ladisch L, Sonne	Cell	2024
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PMID:36917977]	Neel DV, Basu H, Gunner G, Bergstresser	Neuron	2023
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMI in their description or question text

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection

Score: 0.751 · neuroscience · 2026-04-07

## Mechanistic Overview Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection starts from the claim that modulat

SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regula

Score: 0.732 · neurodegeneration · 2026-04-16

**Molecular Mechanism and Rationale** The molecular foundation for SMPD1 inhibition in Alzheimer's disease centers on t

KCNQ2/3 (M-current) Channel Restoration Reactivates Theta Oscillation Dynamics

Score: 0.725 · alzheimers · 2026-04-28

Aβ oligomers downregulate KCNQ2/3 voltage-gated potassium channels on PV interneurons via PKC-dependent phosphorylation,

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.724 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic, Irreversible Stres

Score: 0.700 · neurodegeneration · 2026-04-22

## Mechanistic Overview Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic, Irreversible Stress Granule Comple

Lysosomal Positioning Dynamics Modulation

Score: 0.686 · neurodegeneration · 2026-04-02

## Mechanistic Overview Lysosomal Positioning Dynamics Modulation starts from the claim that modulating LAMP1 within the

Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neurons

Score: 0.680 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The proposed mechanism centers on a complex interplay between gut microbiota,

Cortical Layer 5 Pyramidal Neuron GluN2B-Mediated Hyperactivity Drives Tau Secre

Score: 0.679 · neuroscience · 2026-04-28

Hyperactive GluN2B in L5 corticothalamic neurons increases extracellular glutamate, activating astrocytes and oligodendr

Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker

Score: 0.677 · translational-neuroscience · 2026-04-16

## Mechanistic Overview Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker starts from the claim tha

Lipid Droplet Dynamics as Phenotype Switches

Score: 0.666 · neurodegeneration · 2026-04-02

## Mechanistic Overview Lipid Droplet Dynamics as Phenotype Switches starts from the claim that modulating DGAT1 and SOA