EIF4EBP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4EBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

EIF4EBP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with ALS, Als, Atherosclerosis. Connected to 130 entities in the SciDEX knowledge graph.

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flowchart TD
    EIF4EBP1["EIF4EBP1<br/>Translation Repressor"]
    MTOR["MTOR<br/>Mechanistic Target<br/>of Rapamycin"]
    MTOR_pathway["mTOR Signaling<br/>Pathway"]
    Autophagy["Autophagy<br/>Pathway"]
    MAP1LC3B["MAP1LC3B (LC3)<br/>Autophagosome<br/>Marker"]
    LAMP1["LAMP1<br/>Lysosomal<br/>Membrane"]
    Lysosomal_deg["Lysosomal<br/>Degradation"]
    PPARGC1A["PPARGC1A<br/>Metabolic<br/>Coactivator"]
    Lipid_metabolism["Lipid Metabolism<br/>Pathway"]
    RPS6["RPS6<br/>Ribosomal<br/>Protein S6"]
    MYC["MYC<br/>Transcription<br/>Factor"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    Ischemia["Cerebral<br/>Ischemia"]
    Metabolic_syndrome["Metabolic<br/>Syndrome"]

    MTOR --|"phosphorylates/inhibits"|--> EIF4EBP1
    EIF4EBP1 --|"regulates"|--> MTOR_pathway
    EIF4EBP1 --|"regulates"|--> Autophagy
    EIF4EBP1 --|"regulates"|--> MAP1LC3B
    EIF4EBP1 --|"regulates"|--> LAMP1
    EIF4EBP1 --|"activates"|--> Lysosomal_deg
    EIF4EBP1 --|"regulates"|--> PPARGC1A
    EIF4EBP1 --|"activates"|--> Lipid_metabolism
    EIF4EBP1 --|"regulates"|--> RPS6
    EIF4EBP1 --|"regulates"|--> MYC
    EIF4EBP1 --|"interacts with"|--> ALS
    EIF4EBP1 --|"regulates"|--> MS
    EIF4EBP1 --|"regulates"|--> Ischemia
    EIF4EBP1 --|"activates"|--> Metabolic_syndrome

    style EIF4EBP1 fill:#006494
    style Autophagy fill:#1b5e20
    style Lysosomal_deg fill:#1b5e20
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Ischemia fill:#ef5350
    style Metabolic_syndrome fill:#5d4400
    style MTOR fill:#4a1a6b
    style PPARGC1A fill:#4a1a6b
    style MYC fill:#4a1a6b