gene

EIF4EBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4EBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

326Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EIF4EBP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with ALS, Als, Atherosclerosis. Connected to 130 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	EIF4EBP1
Full Name	Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Aliases	4E-BP1
Function	is a small (~117 amino acid) translational repressor protein that plays a critical role in regulating cap-dependent mRNA translation.
Molecular Weight	12 kDa
Amino Acids	117 aa
Pathways	mTOR, mtor, mTOR signaling
Ensembl ID	ENSG00000187840
GeneCards	EIF4EBP1
Human Protein Atlas	EIF4EBP1
Unphosphorylated 4E-BP1	High affinity for eIF4E, strong translation repression
Phosphorylated 4E-BP1	Reduced eIF4E binding, releases the translational brake
Synaptic proteins	NMDA receptor subunits, AMPA receptor components
Transcription factors	c-Fos, Arc, CREB
Trophic factors	BDNF, NGF
Associated Diseases	Als, Ataxia, Cancer, Infection, Metabolic Syndrome
Known Drugs/Compounds	rapamycin
Interactions	4E-BP1, ABCA1, ABCG1, ACTB, AKT, AKT1
KG Connections	326 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EIF4EBP1 — Eukaryotic Translation Initiation Factor 4E Binding Protein 1

gene · 2611 words

→

EIF4EBP1 Protein (4E-BP1)

protein · 526 words

→

Pathway Diagram

flowchart TD
    EIF4EBP1["EIF4EBP1
Translation Repressor"]
    MTOR["MTOR
Mechanistic Target
of Rapamycin"]
    MTOR_pathway["mTOR Signaling
Pathway"]
    Autophagy["Autophagy
Pathway"]
    MAP1LC3B["MAP1LC3B (LC3)
Autophagosome
Marker"]
    LAMP1["LAMP1
Lysosomal
Membrane"]
    Lysosomal_deg["Lysosomal
Degradation"]
    PPARGC1A["PPARGC1A
Metabolic
Coactivator"]
    Lipid_metabolism["Lipid Metabolism
Pathway"]
    RPS6["RPS6
Ribosomal
Protein S6"]
    MYC["MYC
Transcription
Factor"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    Ischemia["Cerebral
Ischemia"]
    Metabolic_syndrome["Metabolic
Syndrome"]

    MTOR -->|"phosphorylates/inhibits"| EIF4EBP1
    EIF4EBP1 -->|"regulates"| MTOR_pathway
    EIF4EBP1 -->|"regulates"| Autophagy
    EIF4EBP1 -->|"regulates"| MAP1LC3B
    EIF4EBP1 -->|"regulates"| LAMP1
    EIF4EBP1 -->|"activates"| Lysosomal_deg
    EIF4EBP1 -->|"regulates"| PPARGC1A
    EIF4EBP1 -->|"activates"| Lipid_metabolism
    EIF4EBP1 -->|"regulates"| RPS6
    EIF4EBP1 -->|"regulates"| MYC
    EIF4EBP1 -->|"interacts with"| ALS
    EIF4EBP1 -->|"regulates"| MS
    EIF4EBP1 -->|"regulates"| Ischemia
    EIF4EBP1 -->|"activates"| Metabolic_syndrome

    style EIF4EBP1 fill:#006494
    style Autophagy fill:#1b5e20
    style Lysosomal_deg fill:#1b5e20
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Ischemia fill:#ef5350
    style Metabolic_syndrome fill:#5d4400
    style MTOR fill:#4a1a6b
    style PPARGC1A fill:#4a1a6b
    style MYC fill:#4a1a6b

Outgoing (205)

Target	Relation	Type	Str
EIF4F	regulates	protein	0.90
mRNA Translation	regulates	process	0.90
Mrna Translation	modulates	process	0.85
Mtor	activates	pathway	0.70
ROS	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	regulates	disease	0.65
Ataxia	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Ischemia	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Atherosclerosis	activates	disease	0.65
ALS	interacts_with	disease	0.65
PIK3CA	activates	gene	0.60
PSMA1	activates	gene	0.60
PSMB5	activates	gene	0.60
TP53	activates	gene	0.60
cardiovascular disease	activates	disease	0.60
GUSB	activates	gene	0.60
HEXB	activates	gene	0.60
LGALS3	activates	gene	0.60
MCOLN1	activates	gene	0.60
SOX9	activates	gene	0.60
TFEB	activates	gene	0.60
VIM	activates	gene	0.60
ATG	regulates	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Lysosomal Degradation	associated_with	pathway	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
ATP	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Mtor	inhibits	pathway	0.60
MTOR	activates	gene	0.60
SQSTM1	regulates	gene	0.60
ATG5	interacts_with	gene	0.60
GLB1	activates	gene	0.60
MKI67	activates	gene	0.60
PI3K	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (121)

Source	Relation	Type	Str
MTOR	activates	gene	0.90
MTOR	phosphorylates	protein	0.85
ATP	activates	gene	0.70
NBN	associated_with	gene	0.60
TPX2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
MDC1	associated_with	gene	0.60
ATR	associated_with	gene	0.60
MRE11	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
CHEK1	associated_with	gene	0.60
CHMP6	associated_with	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
ABCG1	interacts_with	gene	0.60
CPT1A	activates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
ACTB	regulates	gene	0.60
LOX	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
AKT	inhibits	gene	0.60
SQSTM1	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
PTEN	activates	gene	0.60
RPS6	activates	gene	0.60
RHEB	activates	gene	0.60
AKT1	activates	gene	0.60
RPS6KB1	activates	gene	0.60
PDPK1	activates	gene	0.60
TSC2	activates	gene	0.60
ACTB	activates	entity	0.60
CAT	activates	entity	0.60
CTSD	activates	entity	0.60
PI3K	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
DMSO	activates	gene	0.60
AKT	activates	gene	0.60
CDKN1A	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF4EBP1 in their description or question text

No additional research found