concept

RAPAMYCIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAPAMYCIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1408Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	RAPAMYCIN
Key Genes/Proteins	SQSTM1, RAS, TFEB, ULK1, LAMP1, PI3K

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Novel Therapy Index

idea · 10647 words

→

Pathway Diagram

graph TD
    RAPAMYCIN["RAPAMYCIN"]
    RAPAMYCIN -->|"inhibits"| MTORC1["MTORC1"]
    RAPAMYCIN -->|"inhibits"| MTOR["MTOR"]
    RAPAMYCIN -->|"activates"| SQSTM1["SQSTM1"]
    RAPAMYCIN -->|"activates"| RAS["RAS"]
    RAPAMYCIN -->|"activates"| STEM_CELLS["STEM CELLS"]
    RAPAMYCIN -->|"activates"| TFEB["TFEB"]
    RAPAMYCIN -->|"activates"| ULK1["ULK1"]
    PEROXISOME["PEROXISOME"] -->|"activates"| RAPAMYCIN
    LYSOSOME["LYSOSOME"] -->|"activates"| RAPAMYCIN
    LAMP1["LAMP1"] -->|"activates"| RAPAMYCIN
    PI3K["PI3K"] -->|"activates"| RAPAMYCIN
    AKT["AKT"] -->|"activates"| RAPAMYCIN
    BECN1["BECN1"] -->|"activates"| RAPAMYCIN
    AMPK["AMPK"] -->|"activates"| RAPAMYCIN
    LC3["LC3"] -->|"activates"| RAPAMYCIN

Outgoing (665)

Target	Relation	Type	Str
SQSTM1	activates	gene	0.95
RAS	activates	gene	0.95
STEM CELLS	activates	cell_type	0.95
TFEB	activates	gene	0.95
ULK1	activates	gene	0.95
MTORC1	inhibits	protein	0.87
MTOR	inhibits	gene	0.80
STROKE	inhibits	disease	0.70
AUTOPHAGY	treats	phenotype	0.70
MITOCHONDRIAL DYSFUNCTION	treats	phenotype	0.70
AUTOPHAGY	protects_against	phenotype	0.70
ULK1	produces	gene	0.70
ULK1	inhibits	gene	0.70
APOE	treats	gene	0.70
ROS	activates	protein	0.65
RB1	activates	gene	0.65
RIPK1	phosphorylates	gene	0.65
ROS	phosphorylates	gene	0.65
SQSTM1	phosphorylates	gene	0.65
STAT3	phosphorylates	gene	0.65
STING	phosphorylates	gene	0.65
TFEB	phosphorylates	gene	0.65
SPINAL CORD	targets	brain_region	0.65
TARDBP	activates	gene	0.65
SIRT1	regulates	gene	0.65
TFEB	regulates	gene	0.65
TP53	regulates	gene	0.65
TARDBP	interacts_with	gene	0.65
TFEB	interacts_with	gene	0.65
VCP	activates	gene	0.65
SNAP25	activates	gene	0.65
SYN1	activates	gene	0.65
SQSTM1	interacts_with	gene	0.65
WNT	regulates	gene	0.65
TFEB	targets	gene	0.65
TH	regulates	gene	0.65
VEGF	interacts_with	gene	0.65
STING	treats	gene	0.65
T CELL	treats	cell_type	0.65
SREBF2	activates	gene	0.65
STING	activates	gene	0.65
STING	inhibits	gene	0.65
STING	regulates	gene	0.65
T CELL	regulates	cell_type	0.65
TAU	contributes_to	gene	0.65
SPINAL CORD	expressed_in	brain_region	0.65
PHAGOCYTOSIS	protects_against	phenotype	0.65
CHOLESTEROL	treats	phenotype	0.65
CHOLESTEROL	inhibits	phenotype	0.65
MITOPHAGY	activates	phenotype	0.65

Incoming (743)

Source	Relation	Type	Str
LAMP1	activates	gene	0.95
PI3K	activates	gene	0.95
AKT	activates	gene	0.95
BECN1	activates	gene	0.95
AMPK	activates	gene	0.95
LC3	activates	gene	0.95
P62	activates	gene	0.95
MTOR	therapeutic_target	gene	0.95
MTOR	regulates	gene	0.95
AUTOPHAGY	regulates	process	0.95
GAPDH	activates	gene	0.80
APOPTOSIS	activates	process	0.80
CTSD	activates	gene	0.65
MYC	activates	gene	0.65
MICRORNA REGULATION	activates	process	0.65
ALS	activates	disease	0.65
BCL2	activates	gene	0.65
CREB	activates	gene	0.65
P53	activates	gene	0.65
LAMP2	activates	gene	0.65
CANCER	activates	disease	0.65
MTOR	interacts_with	gene	0.65
MTOR	implicated_in	gene	0.65
ATP	regulates	gene	0.65
ISCHEMIA	regulates	disease	0.65
LAMP1	regulates	gene	0.65
NADH	regulates	gene	0.65
AKT	targets	gene	0.65
MLKL	targets	gene	0.65
OPTN	phosphorylates	gene	0.65
PI3K	phosphorylates	gene	0.65
ALS	interacts_with	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
HUNTINGTON	interacts_with	disease	0.65
LAMP1	interacts_with	gene	0.65
MTOR	targets	gene	0.65
PARKIN	targets	gene	0.65
PARKINSON	targets	disease	0.65
CREB	interacts_with	gene	0.65
LC3	targets	gene	0.65
OPTN	targets	gene	0.65
P62	regulates	gene	0.65
LC3	regulates	gene	0.65
DEMENTIA	interacts_with	disease	0.65
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.65
FTD	interacts_with	disease	0.65
NEURON	interacts_with	cell_type	0.65
PINK1	causes	gene	0.65
ALZHEIMER	expressed_in	disease	0.65
ATG7	expressed_in	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RAPAMYCIN

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

PD Cure Roadmap

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism