| Gene Symbol | ADAM17 |
| Aliases | ADAM17PROTEIN |
| Chromosome | 2p25.1 |
| Protein Family | ADAM (A Disintegrin And Metalloproteinase) family |
| Function | is a transmembrane zinc-dependent metalloproteinase that functions as the primary alpha-secretase for amyloid precursor protein (APP) processing. |
| Subcellular Localization | Plasma membrane, Golgi apparatus, endoplasmic reticulum |
| Molecular Weight | ~93 kDa (proform), ~70 kDa (active form after prodomain removal) |
| Exons | 22 |
| Pathways | Notch, Apoptosis, Stem Cell, Phagocytosis, Amyloid |
| UniProt ID | Q9Y416 |
| GeneCards | ADAM17 |
| Human Protein Atlas | ADAM17 |
| Protein Name | ADAM17 (TACE) |
| Gene | ADAM17 |
| EC Number | 3.4.24.86 |
| Associated Diseases | Cancer, Neurodegeneration |
| Interactions | TAU, LRP1, APOE, IL6, TREM2, APP |
| KG Connections | 175 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |