| Gene Symbol | ADRB1PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | cardiac myocytes where it mediates the positive chronotropic and inotropic effects of catecholamines |
| Subcellular Localization | </b></td><td>Cell membrane, heart and CNS</td></tr> |
| Molecular Weight | 51 kDa |
| GeneCards | ADRB1PROTEIN |
| Human Protein Atlas | ADRB1PROTEIN |
| Cerebellum | Presence in Purkinje cells and granule cell layer |
| Hypothalamus | Regulation of sympathetic outflow |
| Locus coeruleus | Interaction with noradrenergic system |
| Adrb1 knockout mice | Show bradycardia and reduced cardiac stress response |
| Conditional knockout models | Brain-specific deletion reveals role in cognition |
| Transgenic overexpression | Cardiac-specific overexpression leads to cardiomyopathy |
| Conditional KO | Allows temporal control of gene deletion |
| Associated Diseases | neurodegeneration |
| Interactions | ADRA1A, ADRA2A, DBH, ERBB4, IL1RL1, IL33 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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