gene

IL1RL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1RL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections
0Hypotheses
0Analyses
26Outgoing
16Incoming

Summary

IL1RL1 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates, associated with. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIL1RL1
Full NameInterleukin-1 Receptor-Like 1 (ST2)
Chromosome2q12
Protein FamilyIL-1 receptor family
Protein TypeReceptor
FunctionEndogenous alarmin signals danger
Primary ExpressionNuclear localization in structural cells
Molecular Weight63 kDa
Amino Acids556 aa
Exons11
PathwaysMAPK
UniProt IDQ9INT6
NCBI Gene ID9173
Ensembl IDENSG00000115607
OMIM601203
GeneCardsIL1RL1
Human Protein AtlasIL1RL1
Associated DiseasesALS
InteractionsIL33, NRG1, ASTROCYTES, ASTROCYTE, MICROGLIA, ADRA1A
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: IL1RL1 — AlphaFold Q9INT6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

IL1RL1 Gene

gene · 2124 words

Epigenetic Biomarkers in Neurodegenerative Diseases

biomarker · 1956 words

Epigenetic Therapy in Neurodegeneration: Investment Landscape Analysis

investment · 1661 words

Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Markers

experiment · 1363 words

Interleukin-18 Protein

protein · 1299 words

Epigenetic Changes in Progressive Supranuclear Palsy

mechanism · 1237 words

Pathway Diagram

flowchart TD
    N0["IL1RL1"]
    N1["Epigenetic"]
    N0 -->|"associated with"| N1
    N2["ASTROCYTES"]
    N0 -->|"activates"| N2
    N3["ASTROCYTE"]
    N0 -->|"activates"| N3
    N4["PHAGOCYTOSIS"]
    N0 -->|"implicated in"| N4
    N5["AKT"]
    N0 -->|"implicated in"| N5
    N6["MITOCHONDRIA"]
    N0 -->|"implicated in"| N6
    N7["IL33"]
    N0 -->|"activates"| N7
    N8["MICROGLIA"]
    N0 -->|"activates"| N8
    N9["Phagocytosis"]
    N0 -->|"implicated in"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 pathway

Outgoing (26)

TargetRelationTypeStr
AKTimplicated_ingene0.60
IL33activatesgene0.60
IL33interacts_withgene0.60
NRG1interacts_withgene0.60
IL4regulatesgene0.60

Incoming (16)

SourceRelationTypeStr
ADRA1Ainteracts_withgene0.60
ADRA2Ainteracts_withgene0.60
ADRB1interacts_withgene0.60
DBHinteracts_withgene0.60
ERBB4interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found