Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1RL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL1RL1 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates, associated with. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | IL1RL1 |
| Full Name | Interleukin-1 Receptor-Like 1 (ST2) |
| Chromosome | 2q12 |
| Protein Family | IL-1 receptor family |
| Protein Type | Receptor |
| Function | Endogenous alarmin signals danger |
| Primary Expression | Nuclear localization in structural cells |
| Molecular Weight | 63 kDa |
| Amino Acids | 556 aa |
| Exons | 11 |
| Pathways | MAPK |
| UniProt ID | Q9INT6 |
| NCBI Gene ID | 9173 |
| Ensembl ID | ENSG00000115607 |
| OMIM | 601203 |
| GeneCards | IL1RL1 |
| Human Protein Atlas | IL1RL1 |
| Associated Diseases | ALS |
| Interactions | IL33, NRG1, ASTROCYTES, ASTROCYTE, MICROGLIA, ADRA1A |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["IL1RL1"]
N1["Epigenetic"]
N0 -->|"associated with"| N1
N2["ASTROCYTES"]
N0 -->|"activates"| N2
N3["ASTROCYTE"]
N0 -->|"activates"| N3
N4["PHAGOCYTOSIS"]
N0 -->|"implicated in"| N4
N5["AKT"]
N0 -->|"implicated in"| N5
N6["MITOCHONDRIA"]
N0 -->|"implicated in"| N6
N7["IL33"]
N0 -->|"activates"| N7
N8["MICROGLIA"]
N0 -->|"activates"| N8
N9["Phagocytosis"]
N0 -->|"implicated in"| N9
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| AKT | implicated_in | gene | 0.60 |
| IL33 | activates | gene | 0.60 |
| IL33 | interacts_with | gene | 0.60 |
| NRG1 | interacts_with | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| IL7R | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LDH | regulates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| PHAGOCYTOSIS | implicated_in | gene | 0.60 |
| MITOCHONDRIA | implicated_in | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| Phagocytosis | implicated_in | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| MAP1LC3 | regulates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| IL33 | co_expressed_with | protein | 0.50 |
| NRG1 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADRA1A | interacts_with | gene | 0.60 |
| ADRA2A | interacts_with | gene | 0.60 |
| ADRB1 | interacts_with | gene | 0.60 |
| DBH | interacts_with | gene | 0.60 |
| ERBB4 | interacts_with | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| CD31 | regulates | gene | 0.60 |
| CKB | regulates | gene | 0.60 |
| CTS | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| ANXA5 | regulates | gene | 0.60 |
| DBH | co_expressed_with | gene | 0.50 |
| ERBB4 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||