protein

IL33

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL33: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

49Outgoing

30Incoming

Summary

IL33 is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with Als, Depression, Inflammation. Connected to 22 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	IL33
Full Name	Interleukin-33
Chromosome	9p24.1
Function	IL33 is a cytokine with alarmin function:
Molecular Weight	30 kDa
Pathways	MAPK pathway
UniProt ID	Q9BY84
NCBI Gene ID	90865
Ensembl ID	ENSG00000144233
OMIM	608678
GeneCards	IL33
Human Protein Atlas	IL33
N-terminal domain	Chromatin-binding domain
C-terminal domain	Cytokine receptor-binding domain
Full-length form	Biologically active as nuclear protein
Associated Diseases	ALS
Interactions	ZBP1, MLKL, RIPK3, TNF, NRG1, MICROGLIA
KG Connections	79 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL33 — AlphaFold Q9BY84 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL33["<b>IL33</b>"]
    Epigenetic["Epigenetic"]
    IL33 -->|"associated with"| Epigenetic
    Als{"Als"}
    IL33 -->|"inhibits"| Als
    Inflammation{"Inflammation"}
    IL33 -->|"activates"| Inflammation
    ZBP1["ZBP1"]
    IL33 -->|"activates"| ZBP1
    MLKL["MLKL"]
    IL33 -->|"inhibits"| MLKL
    RIPK3["RIPK3"]
    IL33 -->|"inhibits"| RIPK3
    Necroptosis(["Necroptosis"])
    IL33 -->|"activates"| Necroptosis
    neurodegeneration["neurodegeneration"]
    IL33 -->|"implicated in"| neurodegeneration
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| IL33
    style IL33 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (49)

Target	Relation	Type	Str
beige adipocyte	promotes	cell_type	0.90
thermogenesis	promotes	process	0.90
Inflammation	promotes	process	0.90
dural Tregs	activates	cell_type	0.87
metabolic inflammation	drives	process	0.85
Als	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
MONOCYTES	activates	cell_type	0.65
ZBP1	activates	gene	0.60
MLKL	inhibits	gene	0.60
RIPK3	inhibits	gene	0.60
EGFR	expressed_in	gene	0.60
CD33	therapeutic_target	gene	0.60
TNF	activates	gene	0.60
NRG1	interacts_with	gene	0.60
Necroptosis	activates	pathway	0.60
MICROGLIA	activates	gene	0.60
Phagocytosis	implicated_in	pathway	0.60
DEPRESSION	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AND	inhibits	gene	0.60
DNA	activates	gene	0.60
Phagocytosis	therapeutic_target	pathway	0.60
Innate Immunity	therapeutic_target	pathway	0.60
Monocyte	associated_with	cell_type	0.60
Microglia	activates	cell_type	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
Amyloid	activates	pathway	0.60
Innate Immunity	activates	pathway	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
Aβ	associated_with	protein	0.60
Cytokine	activates	protein	0.60
Monocyte	transports	cell_type	0.60
Amyloid	therapeutic_target	protein	0.60
microglia	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
Microglia	expressed_in	cell_type	0.55
MICROGLIA	implicated_in	cell_type	0.55
TNF	co_expressed_with	gene	0.50
NRG1	co_expressed_with	gene	0.50
CYTOKINE	activates	concept	0.50
MONOCYTES	associated_with	concept	0.50

Incoming (30)

Source	Relation	Type	Str
CMKLR1	regulates	gene	0.85
NM1	inhibits	protein	0.85
OBESITY	causes	disease	0.65
IL1RL1	activates	gene	0.60
AKT	implicated_in	gene	0.60
CD33	activates	gene	0.60
CD33	therapeutic_target	gene	0.60
IFNG	activates	gene	0.60
ADRA1A	interacts_with	gene	0.60
ADRA2A	interacts_with	gene	0.60
ADRB1	interacts_with	gene	0.60
DBH	interacts_with	gene	0.60
ERBB4	interacts_with	gene	0.60
IL1RL1	interacts_with	gene	0.60
INFLAMMATION	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
PHAGOCYTOSIS	implicated_in	gene	0.60
MITOCHONDRIA	implicated_in	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
IFNG	co_expressed_with	gene	0.50
ERBB4	co_expressed_with	gene	0.50
IL1RL1	co_expressed_with	gene	0.50
microglia	activates	cell_type	0.50
OBESITY	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL33

Understanding Entity Pages

Summary

Wiki Pages (18)

IL33 Gene

IL1RL1 Gene

Epigenetic Biomarkers in Neurodegenerative Diseases

NLRP7 — NLR Family Pyrin Domain Containing 7

Epigenetic Therapy in Neurodegeneration: Investment Landscape Analysis

Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Markers

Epigenetic Changes in Progressive Supranuclear Palsy

ADRA1A Gene

Epigenetic Clock Reversal Therapy for Neurodegeneration Prevention

Epigenetic Therapies for Neurodegeneration

Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeting

Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disease

DBH Gene

Epigenetic Dysregulation Validation in Parkinson's Disease

IL1RL1 Protein (ST2)

IL33 Protein