| Gene Symbol | ATXN1PROTEIN |
| Function | is a 815 amino acid nuclear protein that plays critical roles in transcriptional regulation and RNA processing. |
| Primary Expression | neural tissues[@matilla1998]: |
| Subcellular Localization | signal (NLS)**: Directs nuclear import 4 |
| GeneCards | ATXN1PROTEIN |
| Human Protein Atlas | ATXN1PROTEIN |
| Co-repressor activity | Interacts with transcription factors including RORα |
| CtBP interaction | Partners with C-terminal binding protein (CtBP) |
| Nuclear import | Associates with importin proteins |
| Gene expression | Modulates neuronal gene expression programs |
| RNA binding | Associates with RNA processing complexes |
| Splicing factors | Interacts with splicing machinery |
| mRNA export | May influence mRNA trafficking |
| Normal range | 6-36 CAG repeats |
| Pathogenic range | 41-83+ CAG repeats |
| Associated Diseases | Ataxia, Huntington's disease, neurodegeneration |
| Interactions | BDNF, CIC, NEURON, PKA |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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