CIC

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CIC (Capicua) is an HMG-box transcriptional repressor involved in neuronal gene regulation, brain development, and disease. Associated with SCA1, SCA2, ataxia, and neurodevelopmental disorders.

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graph TD
    CIC["<b>CIC</b>"]
    Cancer{"Cancer"}
    CIC -->|"biomarker for"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    CIC -->|"biomarker for"| Neurodegeneration
    Ms{"Ms"}
    CIC -->|"biomarker for"| Ms
    Glioma{"Glioma"}
    CIC -->|"biomarker for"| Glioma
    Parkinson{"Parkinson"}
    CIC -->|"activates"| Parkinson
    FUBP1["FUBP1"]
    CIC -->|"associated with"| FUBP1
    H3F3A["H3F3A"]
    CIC -->|"associated with"| H3F3A
    OVERVIEW["OVERVIEW"]
    CIC -->|"biomarker for"| OVERVIEW
    BRAF["BRAF"]
    CIC -->|"associated with"| BRAF
    ATRX["ATRX"]
    CIC -->|"associated with"| ATRX
    IDH1["IDH1"]
    CIC -->|"associated with"| IDH1
    JUN["JUN"]
    CIC -->|"biomarker for"| JUN
    IDH1 -->|"associated with"| CIC
    TERT["TERT"]
    TERT -->|"associated with"| CIC
    JUN -->|"biomarker for"| CIC
    BRAF -->|"associated with"| CIC
    FUBP1 -->|"associated with"| CIC
    H3F3A -->|"associated with"| CIC
    ATRX -->|"associated with"| CIC
    OVERVIEW -->|"biomarker for"| CIC
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| CIC
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| CIC
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"activates"| CIC
    AND["AND"]
    AND -->|"associated with"| CIC
    style CIC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0