protein 618 words KG: BAG3PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

BAG3 Protein

🔬 Protein Info
Gene SymbolBAG3
Full NameBCL2 Associated Athanogene 3
AliasesBAG-3, BIS, MFM6
Chromosome10q25.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~57.5 kDa (575 amino acids)
Amino Acids575 aa
Exons4
PathwaysAutophagy, Complement, Nf-Κb
UniProt IDO95843
GeneCardsBAG3
Human Protein AtlasBAG3
Protein NameBAG3
GeneBAG3
Tissue SpecificityMuscle, neurons, heart
Associated DiseasesALS, ALZHEIMERS_DISEASE, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Astrocyte Phagocytosis
Known Drugs/Compoundsrapamycin
InteractionsATG10, CLOCK, ATG12, HSPB8, BMAL1, STUB1
KG Connections413 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses