| Gene Symbol | CASP8 |
| Full Name | Caspase 8 |
| Chromosome | 2q33 |
| Protein Family | Caspase family, Initiator caspases |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cytoplasm, plasma membrane |
| Molecular Weight | ~55 kDa (proenzyme), ~41 kDa (active subunits) |
| Amino Acids | 80 aa |
| Pathways | Akt, Nf-Κb, Pi3K, Toll-Like Receptor |
| UniProt ID | Q14790 |
| Ensembl ID | ENSG00000164040 |
| GeneCards | CASP8 |
| Human Protein Atlas | CASP8 |
| Protein Name | Caspase-8 |
| Alternative Names | MACH, FLICE, CAP4 |
| Associated Diseases | Als, Autoimmune, Ms, Rheumatoid Arthritis |
| Known Drugs/Compounds | natural products |
| Interactions | SQSTM1, MMP2, CASP3, GBM, CDK4, MCL1 |
| KG Connections | 177 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |