protein 1,545 words KG: CD33PROTEIN 2026-03-29
kind:proteinsection:proteinsstate:published
Contents

CD33 Protein — Cluster of Differentiation 33 (Siglec-3)

🔬 Protein Info
Gene SymbolCD33
AliasesSiglec-3
Chromosome19q13.41
FunctionSialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight67 kDa
Amino Acids354 aa
Exons7
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCardsCD33
Human Protein AtlasCD33
Associated DiseasesALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, Aging
Known Drugs/CompoundsStem Cell Therapy
InteractionsOVERVIEW, PSEN1, BCL2, APP, DAP12, APOE
KG Connections708 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
APOE-Dependent Autophagy Restoration
Score: 0.61
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (7)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in