| Gene Symbol | CD33 |
| Aliases | Siglec-3 |
| Chromosome | 19q13.41 |
| Function | Sialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins |
| Molecular Weight | 67 kDa |
| Amino Acids | 354 aa |
| Exons | 7 |
| Pathways | Apoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic |
| UniProt ID | [P20138](https://www.uniprot.org/uniprot/P20138) |
| GeneCards | CD33 |
| Human Protein Atlas | CD33 |
| Sialic acid binding pocket | Formed by complementary determining regions (CDRs), with conserved arginine (R119) critical for sialic acid recognition |
| Ligand specificity | Prefers α2-6-linked sialic acids over α2-3-linked, distinguishing host from pathogen |
| Self-recognition function | Binds sialylated glycoproteins on host cells, generating an inhibitory "self" signal that prevents autoimmunity |
| Dimerization interface | V-type domains can mediate CD33 homodimerization |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Stem Cell Therapy |
| Interactions | ABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID |
| SciDEX Hypotheses | CD33-Dependent Switch Hypothesis: CD33 Antagonism CD33-Sialic Acid Pathway Modulation in Microglia |
| KG Connections | 657 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!