| Gene Symbol | CRH |
| Aliases | CRHPROTEIN |
| Chromosome | 8q13 |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | The CRH gene encodes prepro-CRH, a precursor peptide that is processed to mature CRH. |
| Mechanism of Action | CRH receptor antagonist blocking stress hormone signaling |
| Primary Expression | brain regions involved in stress and emotion: |
| Subcellular Localization | </strong> Secretory vesicles, dense-core granules</div> |
| Druggability | Low (0.34) |
| Clinical Stage | Approved |
| Amino Acids | 41 aa |
| Pathways | Apoptosis, Blood-Brain Barrier, Complement, HPA-axis, HPA_AXIS |
| UniProt ID | P06850 |
| Ensembl ID | ENSG00000118271 |
| GeneCards | CRH |
| Human Protein Atlas | CRH |
| Associated Diseases | ALS, Addiction, Alopecia Areata, Alzheimer, Cancer |
| Known Drugs/Compounds | dexamethasone |
| Interactions | NR3C1, TNFA, FKBP5, JUN, CRHR1, BDNF |
| SciDEX Target | View Target Profile (10 clinical trials) |
| KG Connections | 649 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |