concept

ADDICTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADDICTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

31Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ADDICTION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ADDICTION["ADDICTION"]
    style ADDICTION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ADDICTION -->|"regulates"| Dopamine_Signaling["Dopamine Signaling"]
    ADDICTION -->|"regulates"| Neuron["/Neuron/"]
    ADDICTION -->|"methylates"| Epigenetic["Epigenetic"]
    ADDICTION -->|"target for"| Immune_Response["Immune Response"]
    ADDICTION -->|"target for"| B_Cell["/B Cell/"]
    ADDICTION -->|"target for"| Autophagy["Autophagy"]
    ADDICTION -->|"target for"| Mtor["Mtor"]
    ADDICTION -->|"activates"| Synaptic_Plasticity["Synaptic Plasticity"]
    ADDICTION -->|"target for"| Stem_Cell["/Stem Cell/"]
    CNO([CNO]) -->|"regulates"| ADDICTION
    TNF_ALPHA([TNF-ALPHA]) -->|"methylates"| ADDICTION
    NR3C1([NR3C1]) -->|"methylates"| ADDICTION
    CRHR1([CRHR1]) -->|"methylates"| ADDICTION
    JUN([JUN]) -->|"methylates"| ADDICTION
    DNA([DNA]) -->|"methylates"| ADDICTION
    DEPRESSION([DEPRESSION]) -->|"methylates"| ADDICTION
    CRHBP([CRHBP]) -->|"methylates"| ADDICTION
    FKBP5([FKBP5]) -->|"methylates"| ADDICTION
    IL_6([IL-6]) -->|"methylates"| ADDICTION

Outgoing (31)

Target	Relation	Type	Str
Dopamine Signaling	regulates	pathway	0.55
Amygdala	associated_with	brain_region	0.55
Ventral Tegmental Area	associated_with	brain_region	0.55
Hypothalamus	associated_with	brain_region	0.55
Basal Ganglia	associated_with	brain_region	0.55
Striatum	associated_with	brain_region	0.55
Neuron	regulates	cell_type	0.55
Epigenetic	methylates	pathway	0.55
Immune Response	therapeutic_target	pathway	0.55
B Cell	therapeutic_target	cell_type	0.55
Autophagy	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Synaptic Plasticity	activates	pathway	0.55
Stem Cell	therapeutic_target	cell_type	0.55
Mtor	activates	pathway	0.55
Oxidative Phosphorylation	associated_with	pathway	0.55
Neuron	associated_with	cell_type	0.55
Dopaminergic	inhibits	cell_type	0.55
Neuron	inhibits	cell_type	0.55
Synaptic Plasticity	contributes_to	pathway	0.55
Neurogenesis	contributes_to	pathway	0.55
Astrocyte	contributes_to	cell_type	0.55
Nf-Κb	therapeutic_target	pathway	0.55
Pi3K/Akt	therapeutic_target	pathway	0.55
Epigenetic	associated_with	pathway	0.55
Cortex	associated_with	brain_region	0.55
Thalamus	associated_with	brain_region	0.55
Neuron	therapeutic_target	cell_type	0.55
Cerebellum	associated_with	brain_region	0.55
Spinal Cord	associated_with	brain_region	0.55
Prefrontal Cortex	associated_with	brain_region	0.55

Incoming (120)

Source	Relation	Type	Str
dopamine signaling	implicated_in	pathway	0.95
Dopamine Signaling	associated_with	pathway	0.90
Dopamine	associated_with	entity	0.90
Psychedelics	treats	compound	0.85
CNO	regulates	gene	0.65
CRH	associated_with	gene	0.65
NR3C1	methylates	gene	0.65
CRHR1	methylates	gene	0.65
JUN	methylates	gene	0.65
FKBP5	methylates	gene	0.65
JUN	therapeutic_target	gene	0.65
MYC	therapeutic_target	gene	0.65
MTOR	therapeutic_target	gene	0.65
FOXP2	associated_with	gene	0.65
DRD2	associated_with	gene	0.65
OPRM1	associated_with	gene	0.65
BDNF	associated_with	gene	0.65
SLC6A4	associated_with	gene	0.65
CHRNA5	associated_with	gene	0.65
OVERVIEW	associated_with	gene	0.65
DRD4	associated_with	gene	0.65
CRH	activates	gene	0.65
GBM	inhibits	gene	0.65
MTOR	activates	gene	0.65
PI3K	inhibits	gene	0.65
GFAP	biomarker_for	gene	0.65
NFKBIA	biomarker_for	gene	0.65
SST	biomarker_for	gene	0.65
SIRT1	therapeutic_target	gene	0.65
NAMPT	therapeutic_target	gene	0.65
HCRTR1	associated_with	gene	0.65
HCRT	associated_with	gene	0.65
HCRTR1	activates	gene	0.65
HCRTR2	activates	gene	0.65
HCRT	activates	gene	0.65
AQP4	therapeutic_target	gene	0.65
VEGF	therapeutic_target	gene	0.65
HO1	therapeutic_target	gene	0.65
NRF2	therapeutic_target	gene	0.65
PKC	therapeutic_target	gene	0.65
BDNF	therapeutic_target	gene	0.65
STAT6	therapeutic_target	gene	0.65
REELIN	therapeutic_target	gene	0.65
NQO1	therapeutic_target	gene	0.65
SOD1	therapeutic_target	gene	0.65
CRHR1	associated_with	gene	0.65
CRH	transports	gene	0.65
JUN	associated_with	gene	0.65
NR3C1	associated_with	gene	0.65
FKBP5	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ADDICTION

Understanding Entity Pages

Wiki Pages (20)

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rgs9

gpcr-signaling

Mesolimbic Dopamine Pathway

Dopamine Signaling Pathway

nfkb-neurodegeneration

Netrin Signaling Pathway in Neurodegeneration

Ventral Pallidum GABAergic Neurons

KCNK9 Gene

GRIK3 - Glutamate Receptor Kainate Type Subunit 3

PD Failed Approaches Autopsy

cureapp-inc

Fear Conditioning

Endocannabinoid Signaling in Neurodegeneration

CHRNB2 Protein — Nicotinic Receptor Beta 2 Subunit

CHRNB3 Gene

TAM Receptor Signaling

ERK1 Protein