protein 679 words KG: HCN2PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

HCN2 Protein - Hyperpolarization-activated Cyclic Nucleotide-gated Channel 2

🔬 Protein Info
Gene SymbolHCN2
Full NameHyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
Chromosome19q13.4
FunctionHCN2 channels are voltage-gated cation channels that pass both Na+ and K+ currents with unusual gating properties.
Primary Expressionthe sinoatrial (SA) node and atrioventricular (AV) node
Subcellular Localization</strong></td><td>Plasma membrane (neuronal dendrites)</td></tr>
Molecular Weight95 kDa
UniProt IDQ9P0R3
NCBI Gene ID6138
Ensembl IDENSG00000145214
OMIM616383
GeneCardsHCN2
Human Protein AtlasHCN2
Associated DiseasesAD, ALS, AMI, ARM, Absence Seizures
InteractionsJUN, HCN1, GENES, AND, EPILEPSY, App
KG Connections81 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in