| Gene Symbol | HCN2 |
| Full Name | Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2 |
| Chromosome | 19q13.4 |
| Function | HCN2 channels are voltage-gated cation channels that pass both Na+ and K+ currents with unusual gating properties. |
| Primary Expression | the sinoatrial (SA) node and atrioventricular (AV) node |
| Subcellular Localization | </strong></td><td>Plasma membrane (neuronal dendrites)</td></tr> |
| Molecular Weight | 95 kDa |
| UniProt ID | Q9P0R3 |
| NCBI Gene ID | 6138 |
| Ensembl ID | ENSG00000145214 |
| OMIM | 616383 |
| GeneCards | HCN2 |
| Human Protein Atlas | HCN2 |
| Six Transmembrane Segments (S1-S6) | Voltage-sensing and pore-forming domains |
| Cyclic Nucleotide-Binding Domain (CNBD) | Located in the C-terminus, binds cAMP |
| Associated Diseases | Absence Seizures, AD, Als, AMI, ARM |
| Interactions | App, EPILEPSY, GENES, HCN, HCN1, JUN |
| KG Connections | 72 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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