protein 821 words KG: HEXAPROTEIN 2026-03-13
kind:proteinsection:proteinsstate:published
Contents

Hexosaminidase A (Hex A) Protein

🔬 Protein Info
Gene SymbolHEXAPROTEIN
Protein FamilyGlycoside hydrolase family 20
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationLysosome
Molecular Weight~110 kDa (heterodimer)
Amino Acids529 aa
UniProt IDP06865
GeneCardsHEXAPROTEIN
Human Protein AtlasHEXAPROTEIN
infobox[@mark2003]
Hexosaminidase A (Hex A)[@kottayil2007]
GeneHEXA
PDB Structures2GJX, 4MT8, 5O7G
GM2 gangliosideGM3 ganglioside
Associated Diseasesdisease
InteractionsRb, DEMENTIA, PARKINSON, PARKINSON'S DISEASE, Α-Synuclein, GBA
KG Connections34 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.48
Complement C1q Mimetic Decoy Therapy
Score: 0.48
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45

Related Analyses (8)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in