| Gene Symbol | HTRA1PROTEIN |
| Protein Type | Protease |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | human tissues, with high expression in the brain, heart, placenta, and skeletal muscle |
| GeneCards | HTRA1PROTEIN |
| Human Protein Atlas | HTRA1PROTEIN |
| Fibronectin | ECM assembly |
| Vitronectin | Cell adhesion |
| Aggrecan | Cartilage/brain ECM |
| Latent TGF-β binding proteins | TGF-β activation |
| α-Synuclein | Aggregate clearance |
| Tau | Phosphorylation/aggregation |
| Approach | Status |
| Small molecule HTRA1 modulators | Preclinical |
| Enzyme replacement therapy | Experimental |
| Associated Diseases | neurodegeneration |
| Interactions | VEGFA, GENETIC LOCI, Proteins, Ras, APOE, AND |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |