protein

VEGFA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1026Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for VEGFA Protein - Vascular Endothelial Growth Factor A

View on Wiki →

🔬 Protein Info

Gene Symbol	VEGFA
Full Name	Vascular Endothelial Growth Factor A
Aliases	Page for VEGFA Protein
Function	VEGF exerts its effects by binding to receptor tyrosine kinases (VEGFR-1/Flt-1 and VEGFR-2/KDR/Flk-1) on endothelial cells and other cell types.
Molecular Weight	24 kDa
Pathways	Akt, Autophagy, Mapk, Oxidative Stress, Pi3K
Ensembl ID	ENSG00000112715
GeneCards	VEGFA
Human Protein Atlas	VEGFA
Associated Diseases	AD, ALI, AMI, Aging, Als, Alzheimer
Known Drugs/Compounds	quercetin
Interactions	NRF2, NOS2, SMARCA4, SF3B1, APOB, TERT
KG Connections	1026 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Cancer["Cancer"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Carcinoma["Carcinoma"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Ms["Ms"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Als["Als"]
    VEGFA["VEGFA"] -->|"Biomarker For"| Neurodegeneration["Neurodegeneration"]
    VEGFA["VEGFA"] -->|"Associated With"| Inflammation["Inflammation"]
    VEGFA["VEGFA"] -->|"Associated With"| Neuroinflammation["Neuroinflammation"]
    VEGFA["VEGFA"] -->|"Biomarker For"| Alzheimer["Alzheimer"]
    IDH1["IDH1"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    IL9["IL9"] -->|"Biomarker For"| VEGFA["VEGFA"]
    SF3B1["SF3B1"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    TERT["TERT"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    SMARCA4["SMARCA4"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    style VEGFA fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Neuroinflammation fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style IDH1 fill:#8d4900,color:#e0e0e0
    style IL9 fill:#8d4900,color:#e0e0e0
    style SF3B1 fill:#8d4900,color:#e0e0e0
    style TERT fill:#8d4900,color:#e0e0e0
    style SMARCA4 fill:#8d4900,color:#e0e0e0

Outgoing (527)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Vascular Permeability	regulates	process	0.95
Diabetic Retinopathy	involved_in	disease	0.95
Diabetic Retinopathy	therapeutic_target	disease	0.95
angiogenesis	promotes	process	0.95
Als	therapeutic_target	disease	0.95
Tumor	therapeutic_target	disease	0.95
Angiogenesis	regulates	process	0.95
Pathological Angiogenesis	promotes	phenotype	0.90
Astrocytes	expressed_in	cell_type	0.90
Angiogenesis	promotes	process	0.90
Cerebrovascular Integrity	biomarker_for	process	0.85
Insomnia	therapeutic_target	disease	0.85
ENDOTHELIAL NITRIC OXIDE SYNTHASE	activates	enzyme	0.80
Retinal Barrier Breakdown	mediates	phenotype	0.80
endothelial cells	expressed_in	cell_type	0.80
Angiogenesis	activates	pathway	0.80
Carcinoma	therapeutic_target	disease	0.75
Als	biomarker_for	disease	0.75
Inflammation	associated_with	disease	0.75
Depression	therapeutic_target	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Ischemia	activates	disease	0.75
Stroke	activates	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Breast Cancer	therapeutic_target	disease	0.75
Als	activates	disease	0.75
SMARCA4	therapeutic_target	gene	0.70
TERT	therapeutic_target	gene	0.70
Tnf Signaling	therapeutic_target	pathway	0.70
pericytes	expressed_in	cell_type	0.70
Wnt	therapeutic_target	pathway	0.70
Mapk	activates	pathway	0.70
JAK	therapeutic_target	gene	0.70
DEPRESSION	therapeutic_target	gene	0.70
endothelial cells	associated_with	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Sickle Cell	biomarker_for	disease	0.65
NOTCH1	regulates	gene	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65

Incoming (499)

Source	Relation	Type	Str
TNF	therapeutic_target	gene	1.00
GENES	therapeutic_target	gene	1.00
HIF1A	upregulates	gene	0.90
AKT1	therapeutic_target	gene	0.90
CANCER	therapeutic_target	gene	0.90
cardamom nanoemulsion	downregulates	compound	0.85
HIF-1Α	upregulates	protein	0.85
AGGF1	activates	gene	0.80
UCHL1	upregulates	protein	0.80
IL6	therapeutic_target	gene	0.80
AKT	therapeutic_target	gene	0.80
PI3K	therapeutic_target	gene	0.80
STAT3	therapeutic_target	gene	0.80
INFLAMMATION	associated_with	gene	0.80
JUN	therapeutic_target	gene	0.70
EGFR	therapeutic_target	gene	0.70
BDNF	associated_with	gene	0.70
BAX	activates	gene	0.70
TP53	therapeutic_target	gene	0.70
VEGF	activates	gene	0.70
TNF	associated_with	gene	0.70
AKT1	targets	gene	0.70
TNF	targets	gene	0.70
IL-6	activates	gene	0.70
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.70
IL-6	associated_with	gene	0.70
CYTOKINES	biomarker_for	gene	0.70
TNF-Α	therapeutic_target	gene	0.70
TH	activates	gene	0.65
TH	regulates	gene	0.65
LACTATE	causes	phenotype	0.65
ASTROCYTE	interacts_with	cell_type	0.65
FERROPTOSIS	targets	phenotype	0.65
AMYLOID	interacts_with	protein	0.65
WNT SIGNALING	produces	pathway	0.65
IDH1	therapeutic_target	gene	0.60
IL9	biomarker_for	gene	0.60
SF3B1	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
MCL1	therapeutic_target	gene	0.60
SQSTM1	biomarker_for	gene	0.60
CHIT1	associated_with	gene	0.60
FGF2	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
CHI3L1	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VEGFA

Understanding Entity Pages

Summary

Wiki Pages (21)

VEGFA — Vascular Endothelial Growth Factor A

vegfr-signaling-neurodegeneration

TNF Signaling Pathway in Neurodegeneration

Microglial Proteins in CSF Reveal AD Progression States

eef1a1

SF3B1

Wnt Signaling Dysfunction in Neurodegenerative Diseases

LEF1

Ubiquitin C-terminal Hydrolase L1 (UCH-L1)

FLT1 Gene

Blood-Brain Barrier Dysfunction Pathway

nrp1

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

Neurogenesis Disease Comparison

Neurotrophic Factor Signaling Decline in Neurodegeneration

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

SLC9A2 — Solute Carrier Family 9 Member 2 (Na+/H+ Exchanger 2)

KDR Gene

HIF Signaling in Neurodegeneration