protein

VEGFA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

973Connections

1Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

Page for VEGFA Protein - Vascular Endothelial Growth Factor A

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🔬 Protein Info

Gene Symbol	VEGFA
Full Name	Vascular Endothelial Growth Factor A
Aliases	Page for VEGFA Protein
Function	VEGF exerts its effects by binding to receptor tyrosine kinases (VEGFR-1/Flt-1 and VEGFR-2/KDR/Flk-1) on endothelial cells and other cell types.
Molecular Weight	24 kDa
Pathways	Akt, Autophagy, Mapk, Oxidative Stress, Pi3K
Ensembl ID	ENSG00000112715
GeneCards	VEGFA
Human Protein Atlas	VEGFA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	quercetin
Interactions	ACTB, AGGF1, AKT, AKT1, ALS, ALZHEIMER
SciDEX Hypotheses	Spinal Vascular Unit Breakdown as Universal Driver
KG Connections	972 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VEGFA — Vascular Endothelial Growth Factor A

gene · 731 words

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VEGFA Protein - Vascular Endothelial Growth Factor A

protein · 586 words

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Pathway Diagram

graph TD
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Cancer["Cancer"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Carcinoma["Carcinoma"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Ms["Ms"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Als["Als"]
    VEGFA["VEGFA"] -->|"Biomarker For"| Neurodegeneration["Neurodegeneration"]
    VEGFA["VEGFA"] -->|"Associated With"| Inflammation["Inflammation"]
    VEGFA["VEGFA"] -->|"Associated With"| Neuroinflammation["Neuroinflammation"]
    VEGFA["VEGFA"] -->|"Biomarker For"| Alzheimer["Alzheimer"]
    IDH1["IDH1"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    IL9["IL9"] -->|"Biomarker For"| VEGFA["VEGFA"]
    SF3B1["SF3B1"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    TERT["TERT"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    SMARCA4["SMARCA4"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    style VEGFA fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Neuroinflammation fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style IDH1 fill:#8d4900,color:#e0e0e0
    style IL9 fill:#8d4900,color:#e0e0e0
    style SF3B1 fill:#8d4900,color:#e0e0e0
    style TERT fill:#8d4900,color:#e0e0e0
    style SMARCA4 fill:#8d4900,color:#e0e0e0

Outgoing (520)

Target	Relation	Type	Str
VEGFA	encodes	protein	0.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	0.95
Tumor	therapeutic_target	disease	0.95
Angiogenesis	regulates	process	0.95
angiogenesis	promotes	process	0.95
Diabetic Retinopathy	therapeutic_target	disease	0.95
Vascular Permeability	regulates	process	0.95
Diabetic Retinopathy	involved_in	disease	0.95
Pathological Angiogenesis	promotes	phenotype	0.90
angiogenesis	associated_with	phenotype	0.90
Angiogenesis	promotes	process	0.90
Astrocytes	expressed_in	cell_type	0.90
Cerebrovascular Integrity	biomarker_for	process	0.85
Insomnia	therapeutic_target	disease	0.85
Retinal Barrier Breakdown	mediates	phenotype	0.80
endothelial cells	expressed_in	cell_type	0.80
ENDOTHELIAL NITRIC OXIDE SYNTHASE	activates	enzyme	0.80
Angiogenesis	activates	pathway	0.80
Fibrosis	therapeutic_target	disease	0.75
Stroke	activates	disease	0.75
Ischemia	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Depression	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
Als	biomarker_for	disease	0.75
Als	activates	disease	0.75
Breast Cancer	therapeutic_target	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
vascular permeability	increases	process	0.70
angiogenesis	activates	process	0.70
endothelial cells	associated_with	cell_type	0.70
JAK	therapeutic_target	gene	0.70
TERT	therapeutic_target	gene	0.70
SMARCA4	therapeutic_target	gene	0.70
Wnt	therapeutic_target	pathway	0.70
pericytes	expressed_in	cell_type	0.70
blood-spinal cord barrier breakdown	causes	phenotype	0.70
MAPK signaling	participates_in	pathway	0.70
Mapk	activates	pathway	0.70
DEPRESSION	therapeutic_target	gene	0.70
Tnf Signaling	therapeutic_target	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
mitochondrial transfer	modulates	process	0.70
Neurovascular unit dysfunction	modulates	mechanism	0.70
Vascular Dysfunction	regulates	phenotype	0.70
vascular dysfunction	regulates	phenotype	0.70
CALCIUM SIGNALING	regulates	pathway	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65

Incoming (453)

Source	Relation	Type	Str
VEGFA	encodes	gene	0.00
TNF	targets	gene	1.00
GENES	therapeutic_target	gene	1.00
HIF1A	upregulates	gene	0.90
AKT1	targets	gene	0.90
CANCER	therapeutic_target	gene	0.90
cardamom nanoemulsion	downregulates	compound	0.85
HIF-1Α	upregulates	protein	0.85
AGGF1	activates	gene	0.80
UCHL1	upregulates	protein	0.80
IL6	targets	gene	0.80
STAT3	therapeutic_target	gene	0.80
PI3K	therapeutic_target	gene	0.80
AKT	therapeutic_target	gene	0.80
INFLAMMATION	associated_with	gene	0.80
HIF1A	regulates	protein	0.70
CYTOKINES	biomarker_for	gene	0.70
BDNF	associated_with	gene	0.70
VEGF	activates	gene	0.70
IL-6	associated_with	gene	0.70
EGFR	targets	gene	0.70
BAX	activates	gene	0.70
JUN	targets	gene	0.70
TNF	associated_with	gene	0.70
TP53	targets	gene	0.70
TNF-Α	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.70
IL-6	activates	gene	0.70
LACTATE	causes	phenotype	0.65
AMYLOID	interacts_with	protein	0.65
TH	regulates	gene	0.65
TH	activates	gene	0.65
FERROPTOSIS	targets	phenotype	0.65
ASTROCYTE	interacts_with	cell_type	0.65
WNT SIGNALING	associated_with	pathway	0.65
APOE	biomarker_for	gene	0.60
MMP9	associated_with	gene	0.60
TP53	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
MCC	associated_with	gene	0.60
EGF	associated_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
FOXO3	associated_with	gene	0.60
CAT	associated_with	gene	0.60
IL2	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
AXIN1	therapeutic_target	gene	0.60