concept

GENETIC LOCI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GENETIC LOCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

44Outgoing

18Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GENETIC LOCI
Key Genes/Proteins	DIABETIC RETINOPATHY, AND, APOPTOSIS, MIRNAS
Related Diseases	ALS Reversal, Diabetes, Parkinson, Amyotrophic Lateral Sclerosis, Alzheimer
Related Pathways	Oxidative Stress, Apoptosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GENETIC_LOCI["GENETIC LOCI"]
    GENETIC_LOCI -->|"correlates_with"| ALS_Reversal["ALS Reversal"]
    GENETIC_LOCI -->|"causes"| Diabetes["Diabetes"]
    GENETIC_LOCI -->|"interacts"| Parkinson["Parkinson"]
    GENETIC_LOCI -->|"interacts"| ALS["ALS"]
    GENETIC_LOCI -->|"causes"| DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    GENETIC_LOCI -->|"causes"| APOPTOSIS["APOPTOSIS"]
    GENETIC_LOCI -->|"causes"| MIRNAS["MIRNAS"]
    GENETIC_LOCI -->|"causes"| Oxidative_Stress["Oxidative Stress"]
    PKC["PKC"] -->|"causes"| GENETIC_LOCI
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"causes"| GENETIC_LOCI
    NF__B["NF-KappaB"] -->|"causes"| GENETIC_LOCI
    GENES["GENES"] -->|"interacts"| GENETIC_LOCI
    PARKINSON["PARKINSON"] -->|"interacts"| GENETIC_LOCI
    HTRA1["HTRA1"] -->|"interacts"| GENETIC_LOCI
    APOPTOSIS -->|"causes"| GENETIC_LOCI

Outgoing (47)

Target	Relation	Type	Str
ALS Reversal	correlates_with	phenotype	0.90
Diabetes	causes	disease	0.65
Parkinson	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
DIABETIC RETINOPATHY	causes	gene	0.60
AND	associated_with	gene	0.60
APOPTOSIS	causes	gene	0.60
MIRNAS	causes	gene	0.60
Oxidative Stress	causes	pathway	0.60
Apoptosis	causes	pathway	0.60
Epigenetic	causes	pathway	0.60
Nf-Κb	causes	pathway	0.60
AND	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
Alpha-Synuclein	interacts_with	pathway	0.60
MET	associated_with	gene	0.60
ALS	associated_with	gene	0.60
RS7529220	associated_with	gene	0.60
RNA	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
PKC	causes	gene	0.60
NF-ΚB	causes	gene	0.60
GENES	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
PLEC	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
PKC	causes	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
NF-ΚB	causes	gene	0.60
GENES	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PLEC	associated_with	gene	0.60
HTRA1	interacts_with	gene	0.60
APOE	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
APOPTOSIS	causes	gene	0.60
MET	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GENETIC LOCI

Understanding Entity Pages

Wiki Pages (20)

psp-tauopathy

prion-disease

Cerebral Small Vessel Disease

Sporadic Alzheimer's Disease Pathway

MSA Genetics and Risk Factors

BIN1 — Bridging Integrator 1

alzheimers-research-uk

curepsp-genetics-program

CLU — Clusterin (Apolipoprotein J)

JOIN — Junctlophilin Family Member

MME (Membrane Metalloendopeptidase / Neprilysin)

spinal-cord

Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE)

LATE (Limbic-Predominant Age-Related TDP-43 Encephalopathy)

MS4A1 — Membrane Spanning 4-Domains A1 (CD20)

GWAS Findings Hub: Alzheimer's and Parkinson's Disease

C9orf72 ALS-FTD Phenotype Divergence

GWAS Findings Hub