| Gene Symbol | IRISIN |
| Aliases | IRISINPROTEIN |
| Function | Irisin acts as a systemic mediator, conveying the benefits of exercise to distant tissues including the brain. |
| Molecular Weight | 12 kDa |
| Amino Acids | 112 aa |
| Pathways | Mitochondrial Function, Synaptic Plasticity |
| GeneCards | IRISIN |
| Human Protein Atlas | IRISIN |
| 2012 | Irisin was first described by Boström et al. in Nature[@bostrm2012] |
| Name origin | Named after Iris, the Greek goddess who crossed between heaven and earth |
| Rationale | Irisin crosses the blood-brain barrier and mediates exercise effects on the brain |
| Associated Diseases | Alzheimer'S Disease, DIABETES, disease, Insulin Sensitivity, Neurodegenerative Diseases, OBESITY |
| Interactions | ALZHEIMER, AMPK, AMYLOID, BDNF, BMP2, FGF2 |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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