protein 656 words KG: KCNN4PROTEIN 2026-03-13
kind:proteinsection:proteinsstate:published
Contents

KCNN4 Protein (Small Conductance Calcium-Activated Potassium Channel 4)

🔬 Protein Info
Gene SymbolKCNN4
Full NamePotassium Calcium-Activated Channel Subfamily N Member 4
AliasesSK4, IK1, Small Conductance Calcium-Activated Potassium Channel 4
Chromosome19q13.2
Protein TypeIon channel (intermediate-conductance Ca²⁺-activated K⁺)
Functionis an intermediate-conductance calcium-activated potassium channel that plays critical roles in immune cell activation, erythrocyte volume regulation, epithelial secretion, and neuroinflammation.
Primary ExpressionErythrocytes, immune cells, brain (glia), salivary glands
Molecular Weight71 kDa
PathwaysInteraction
UniProt IDQ9UQM4
NCBI Gene ID3782
Ensembl IDENSG00000104970
OMIM604270
GeneCardsKCNN4
Human Protein AtlasKCNN4
Associated DiseasesCancer
InteractionsAPOPTOSIS, NEURON, CYTOKINES, Ras, RNA
KG Connections127 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in