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protein 667 words KG: LIG4PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

DNA Ligase IV Protein

🔬 Protein Info
Gene SymbolLIG4PROTEIN
Chromosome13q33
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localizationsome tumors ## Therapeutic Targeting **Therapeutic approaches:** - **Gene the
Molecular Weight100 kDa
GeneCardsLIG4PROTEIN
Human Protein AtlasLIG4PROTEIN
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (15)

Epigenetic reprogramming in aging neurons
neurodegeneration · completedWhat determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failedHow does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failedWhat upstream mechanisms cause TDP-43 to trigger mPTP openin
neurodegeneration · failedHow do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completed

Related Experiments (30)

GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · proposed · Score: 0.95cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95Factor depletion effects on DDR focus formation in vivo
exploratory · proposed · Score: 0.90Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in
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