| Gene Symbol | LIPA |
| Full Name | Lysosomal Acid Lipase (LIPA) |
| Protein Type | Enzyme |
| Function | LIPA encodes lysosomal acid lipase (LIPA or LAL), a crucial enzyme that hydrolyzes cholesteryl esters and triglycerides in the lysosome. |
| Primary Expression | neurons, astrocytes, and microglia, with particular importance in lipid-rich region |
| Subcellular Localization | ** Lysosome |
| Pathways | Cholesterol, Alpha-Synuclein, Lipid Metabolism, Phagocytosis, Apoptosis |
| UniProt ID | Search UniProt |
| Ensembl ID | ENSG00000107796 |
| GeneCards | LIPA |
| Human Protein Atlas | LIPA |
| Associated Diseases | ALS, Alzheimer |
| Interactions | SLC17A5, GNPTAB, SMPD1, NPC1, GBA, CTSD |
| KG Connections | 169 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |