| Gene Symbol | NEK7 |
| Aliases | NEK7PROTEIN |
| Protein Type | Serine/Threonine Kinase |
| Function | NEK7 is a 34 kDa serine/threonine kinase that plays dual roles in cell biology: |
| Subcellular Localization | </td><td>Cytoplasm, centrosome</td></tr> |
| Molecular Weight | 34 kDa |
| Pathways | Inflammasome |
| Ensembl ID | ENSG00000151414 |
| GeneCards | NEK7 |
| Human Protein Atlas | NEK7 |
| Activation segment | Contains the conserved DFG motif and T-loop with Thr187 as the activating phosphorylation site |
| C-lobe of NEK7 | Arg121, Glu122, Leu160, and Arg163 form hydrogen bonds with NLRP3 LRR |
| Back of the kinase domain | Additional contacts with the NLRP3 NACHT domain enable bridging between adjacent NLRP3 protomers |
| Associated Diseases | Als, Carcinoma, Encephalitis, Inflammation, Ms, Multiple Sclerosis |
| Interactions | NLRP3, UBIQUITIN, CGAS, STING, TLR4, RELA |
| KG Connections | 144 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |