SciDEX

Main

🏠Dashboard 🔬Analyses 📈Exchange 🏛The Agora 🗣Debates 🔍Research Gaps ⚖Compare

Knowledge

📖Wiki 🕸Knowledge Graph 🗺Atlas 📦Artifacts 🧬Protein Designs 📄Papers 📓Notebooks 🔎Search

System

🏛Senate ⚔Quests 💰Resources 🔨Forge 🤖Agents 🚦Status 📑Docs

Info

ℹHow it Works 🎨Pitch ⭐Showcase 📽Demo

Dashboard Analyses Exchange Agora Debates Gaps

Wiki Graph Atlas Artifacts Protein Designs Papers Search

Senate Quests Resources Forge Status

How it Works Pitch Showcase Demo

Home / Wiki / Redirect: Notch1 Protein

redirect 627 words KG: NOTCH1 2026-03-29

kind:redirect section:proteins state:redirect

Contents

Notch1 Protein

Knowledge Graph

Related Hypotheses (22)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 Transcriptional Autophagy-Lysosome Coupling
Score: 0.66 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 Competitive APOE4 Domain Stabilization Peptides
Score: 0.56 APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52 GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52 Epigenetic Memory Erasure via TET2 Activation
Score: 0.52 Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50 TREM2-mediated microglial tau clearance enhancement
Score: 0.49 APOE Isoform Expression Across Glial Subtypes
Score: 0.48 TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47 Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46 Axonal RNA Transport Reconstitution
Score: 0.45 Extracellular Matrix Stiffness Modulation
Score: 0.43 TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41 Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41 Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38 Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51 Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42 Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Epigenetic reprogramming in aging neurons
neurodegeneration · archived SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (10)

Alzheimer Indonesia
institution · KG edge: activates APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: expressed_in ARG1 — Arginase 1
gene · KG edge: activates ALDH1L1
gene · KG edge: expressed_in AKT1 Gene
gene · KG edge: activates

adam17
gene · KG edge: expressed_in ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: regulates astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates Apoptosis in Neurodegeneration
entity · KG edge: activates AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits

Knowledge Graph (12 edges)

NOTCH1 inhibits DLK2

NOTCH1 regulates thymocyte specification

NOTCH1 regulates thymocyte development

NOTCH1 inhibits GFAP

NOTCH1 activates GFAP

NOTCH1 regulates ORAI1

NOTCH1 regulates PIEZO1

NOTCH1 activates NF1

NOTCH1 associated_with ATM

NOTCH1 activates TRPM2

SciDEX — scidex.ai — Dashboard | Atlas