gene 1,643 words KG: ARG1
Contents

ARG1 — Arginase 1

🧬 Gene Info
Gene SymbolARG1
Full NameArginase 1
AliasesArginase-1, Liver arginase
Chromosome6q23.2
FunctionUrea cycle enzyme, hydrolyzes arginine to ornithine
Primary Expressionthe brain, where it plays important roles in modulating nitric oxide (NO) production, polyamine synthesis, and immune cell function[^2]
Molecular Weight34.7 kDa
Amino Acids330
PathwaysUrea cycle, Arginine metabolism
UniProt IDP05089
NCBI Gene ID383
Ensembl IDENSG00000118520
OMIM608313
GeneCardsARG1
Human Protein AtlasARG1
Associated DiseasesAging, Alzheimer, Cancer, Dementia, Ms, Tumor
InteractionsABCA1, ABCG1, AHR, AKT, AMPK, AND
KG Connections223 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.80
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
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Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (1)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95

See Also (12)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with

Knowledge Graph (12 edges)

PENK expressed_in ARG1
NCAM1 expressed_in ARG1
DNMT1 expressed_in ARG1
AKT1 expressed_in ARG1
COMT expressed_in ARG1
DLGAP2 expressed_in ARG1
STAT3 expressed_in ARG1
ARG1 expressed_in DRD2
ARG1 expressed_in DNMT3A
ARG1 activates MAP1LC3B

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