gene 1,643 words KG: ARG1 2026-03-24
section:geneskind:genetopic:alzheimerstopic:parkinsonstopic:alstopic:neuroinflammation
Contents

ARG1 — Arginase 1

🧬 Gene Info
Gene SymbolARG1
Full NameArginase 1
AliasesArginase-1, Liver arginase
Chromosome6q23.2
FunctionUrea cycle enzyme, hydrolyzes arginine to ornithine
Primary Expressionthe brain, where it plays important roles in modulating nitric oxide (NO) production, polyamine synthesis, and immune cell function[^2]
Molecular Weight34.7 kDa
Amino Acids330
PathwaysUrea cycle, Arginine metabolism
UniProt IDP05089
NCBI Gene ID383
Ensembl IDENSG00000118526
OMIM608313
GeneCardsARG1
Human Protein AtlasARG1
Associated DiseasesAging, Alzheimer, Cancer, Dementia, Ms, Tumor
InteractionsABCG1, TNF, ATG5, PI3K, P62, CD36
KG Connections226 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (15)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
ATG7 Gene
gene · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: inhibits
AKT1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

ARG1 expressed_in DRD2
ARG1 expressed_in DNMT3A
ARG1 interacts_with ABCG1
ARG1 interacts_with TNF
ARG1 inhibits ATG5
ARG1 inhibits PI3K
ARG1 inhibits P62
ARG1 inhibits CD36
ARG1 inhibits LC3
ARG1 inhibits AKT