| Gene Symbol | ADAM17 |
| Chromosome | 2p25.1 |
| Function | is a transmembrane zinc-dependent metalloproteinase that functions as the primary alpha-secretase for amyloid precursor protein (APP) processing. |
| Exons | 22 |
| Pathways | Notch, Apoptosis, Stem Cell, Phagocytosis, Amyloid |
| GeneCards | ADAM17 |
| Human Protein Atlas | ADAM17 |
| TIMP3 | Inhibitor |
| TIMP1 | Inhibitor |
| RACK1 | Adaptor |
| MAD2 | Adaptor |
| Associated Diseases | Cancer, Neurodegeneration |
| Interactions | TAU, LRP1, APOE, IL6, TREM2, APP |
| KG Connections | 175 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |