| Gene Symbol | ABCB1 |
| Full Name | ATP Binding Cassette Subfamily B Member 1 |
| Chromosome | 7q21.12 |
| Protein Type | Transporter |
| Target Class | Transporter |
| Function | encodes a 170 kDa ATP-dependent efflux transporter that is a critical component of the blood-brain barrier. |
| Mechanism of Action | Small molecule inhibitors to reduce efflux pump activity and enhance CNS drug penetration |
| Primary Expression | the cortex and hippocampus, with moderate levels in the cerebellum and brainstem |
| Druggability | Medium (0.47) |
| Clinical Stage | Phase III |
| Molecular Weight | 170 kDa |
| Exons | 29 |
| Pathways | Apoptosis, Blood-Brain Barrier, Ferroptosis, Nf-Κb, Notch |
| Ensembl ID | ENSG00000085563 |
| GeneCards | ABCB1 |
| Human Protein Atlas | ABCB1 |
| Associated Diseases | AD, Aging, Als, Alzheimer |
| Known Drugs/Compounds | Tariquidar, Elacridar |
| Interactions | ABCG2, ACOX1, Actin, AKT, APOD, APOPTOSIS |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 592 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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