gene 1,373 words KG: AKT1 2026-03-29
section:geneskind:genetopic:alzheimerstopic:parkinsonstopic:huntingtonstopic:als
Contents

AKT1 Gene

🧬 Gene Info
Gene SymbolAKT1
Full NameAKT Serine/Threonine Kinase 1
Chromosome14q32.33
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Molecular Weight~56 kDa
Amino Acids480 aa
Exons14 coding exons
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mapk
UniProt IDP31749
NCBI Gene ID207
Ensembl IDENSG00000142208
OMIM164730
GeneCardsAKT1
Human Protein AtlasAKT1
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's Disease, Ataxia
Known Drugs/CompoundsCOUMESTROL, Coumestrol, Atbc, DMP, Andrographis paniculata, quercetin
InteractionsSQSTM1, RPS6KB1, GRB2, RHEB, STING1, EIF2A
KG Connections1615 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3
gene · KG edge: associated_with
AKT3 Gene
gene · KG edge: associated_with
AKT2 Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

AKT1 regulates CALCOCO2
AKT1 regulates CGAS
AKT1 regulates CFTR
AKT1 interacts_with SQSTM1
AKT1 interacts_with RPS6KB1
AKT1 interacts_with GRB2
AKT1 interacts_with RHEB
AKT1 interacts_with STING1
AKT1 interacts_with EIF2A
AKT1 interacts_with LRRK2