| Gene Symbol | NPC1 |
| Aliases | NPC1PROTEIN |
| Chromosome | 18q11.2 |
| Protein Type | Transporter |
| Function | It functions as a key transporter in the late endosomal/lysosomal (LE/LY) system[4] |
| Subcellular Localization | the limiting membrane of lysosomes and late endosomes, where it mediates the egress of cholesterol and other lipids from |
| Pathways | Wnt signaling pathway |
| GeneCards | NPC1 |
| Human Protein Atlas | NPC1 |
| NPC2 Protein | Functional partner in cholesterol trafficking |
| Lysosomal Storage Disorders | Broader disease category |
| Cholesterol Metabolism | Related lipid homeostasis pathway |
| Autophagy | Connected cellular clearance mechanism |
| Sphingolipidoses | Related lipid storage pathologies |
| Associated Diseases | Als, Ms, Neurodegeneration, Niemann-Pick Type C1 Disease, Niemann-Pick disease type C1, Niemann_Pick_disease |
| Interactions | STING1, STING, CD63, CGAS, VAPB, GBA |
| KG Connections | 240 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |