| Gene Symbol | PRESENILIN1 |
| Chromosome | 14q24.2. |
| Protein Family | Presenilin family (intramembrane aspartyl protease) |
| Pathways | Cholesterol Metabolism, Amyloid, Neuroinflammatory, Complement, Cholesterol |
| GeneCards | PRESENILIN1 |
| Human Protein Atlas | PRESENILIN1 |
| Gene [@refa]
[PSEN1](/entities/psen1) [@refb]
[@refc]
[@refd]
UniProt [@refe]
P49768 [@page2026]
[@psen]
[@alzheimers]
PDB Structures [@amyloidbetaproteinsamyloidbeta]
5A63, 6IDF, 6IYC [@gammasecretase]
[@psena]
[@alzheimersa]
Molecular Weight [@amyloidbetaproteinsamyloidbetaa]
52 kDa [@gammasecretasea]
[@amyloidbeta]
[@betasecretase]
Localization | Endoplasmic reticulum, Golgi, cell membrane (γ-secretase complex) |
| Associated Diseases | neurodegeneration |
| Interactions | APP, BACE1, Presenilin, AMYLOID, ALZHEIMER'S DISEASE, Amyloid Beta |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |