SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
entity 1,985 words KG: PRESENILIN
Contents

Presenilin-1 (PS1)

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

Wikipedia

Related Hypotheses (28)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69LRP1-Dependent Tau Uptake Disruption
Score: 0.60Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72
pg 1/2Next →

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (9)

Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90Selective Neuronal Vulnerability to Aging — Mapping Why Spec
validation · proposed · Score: 0.40MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causesADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activatesAKT1 Gene
gene · KG edge: associated_withActin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussedPackard Center for ALS Research
institution · KG edge: co_discussed

Knowledge Graph (12 edges)

PRESENILIN regulates AMYLOID_BETA
PRESENILIN causes FAMILIAL_AD
MFN1 interacts_with PRESENILIN
DNM1L interacts_with PRESENILIN
DDIT3 interacts_with PRESENILIN
ABCD3 interacts_with PRESENILIN
LMNA interacts_with PRESENILIN
MAP1LC3B interacts_with PRESENILIN
OPTN interacts_with PRESENILIN
AMBRA1 interacts_with PRESENILIN

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas