protein

PRESENILIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRESENILIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1075Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

PRESENILIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with ALS, Aging, Als. Connected to 477 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PRESENILIN
Chromosome	14q24.2
Primary Expression	Ca1, Hippocampus, Cortex, Parietal Lobe, Gray Matter
Pathways	autophagy pathway, proteasome pathway, Oxidative Stress, Apoptosis, Autophagy
GeneCards	PRESENILIN
Human Protein Atlas	PRESENILIN
[app](/genes/app)	Generates amyloid-beta peptides of varying lengths (Aβ37–43)
E-cadherin	Cell adhesion molecule; cleavage modulates cell-cell contacts
ErbB4	Receptor tyrosine kinase; cleavage releases signaling domain
ER calcium regulation	PS1 functions as an ER calcium leak channel; FAD mutations reduce this function, increasing ER calcium stores and sensitizing neurons to calcium-dependent excitotoxicity
Wnt/β-catenin signaling	PS1 interacts with β-catenin and gsk3-beta, modulating Wnt signaling independently of Notch processing
Protein trafficking	Facilitates transport of proteins through the ER-Golgi secretory pathway
Predominantly missense mutations	Single amino acid substitutions affecting gamma-secretase processivity
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
Interactions	DNA, CANX, MIRO1, EIF2S1, CAT, LC3
KG Connections	1035 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRESENILIN["PRESENILIN"] -->|"Causes"| FAMILIAL_AD["FAMILIAL_AD"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Dementia["Dementia"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Als["Als"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Parkinson["Parkinson"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Ms["Ms"]
    PRESENILIN["PRESENILIN"] -->|"Associated With"| Neurodegeneration["Neurodegeneration"]
    MFN1["MFN1"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    DNM1L["DNM1L"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    DDIT3["DDIT3"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    ABCD3["ABCD3"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    LMNA["LMNA"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    style PRESENILIN fill:#0d47a1,color:#e0e0e0
    style FAMILIAL_AD fill:#b71c1c,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style MFN1 fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style DDIT3 fill:#8d4900,color:#e0e0e0
    style ABCD3 fill:#8d4900,color:#e0e0e0
    style LMNA fill:#8d4900,color:#e0e0e0

Outgoing (603)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	1.00
AMYLOID	associated_with	gene	1.00
Als	associated_with	disease	0.95
Alzheimer	therapeutic_target	disease	0.95
APP	associated_with	gene	0.90
ALZHEIMER'S DISEASE	associated_with	gene	0.90
autophagy pathway	regulates	pathway	0.88
proteasome pathway	regulates	pathway	0.88
Als	regulates	disease	0.85
Aging	associated_with	disease	0.85
Dementia	associated_with	disease	0.85
AMYLOID	therapeutic_target	gene	0.80
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.80
Neurodegeneration	associated_with	disease	0.75
Neurodegeneration	regulates	disease	0.75
Alzheimer	regulates	disease	0.75
Alzheimer	activates	disease	0.75
Dementia	causes	disease	0.75
Alzheimer	causes	disease	0.75
FAMILIAL_AD	causes	disease	0.72
PSEN1	associated_with	gene	0.70
Oxidative Stress	regulates	pathway	0.70
GENES	associated_with	gene	0.70
CTSD	associated_with	gene	0.70
DEMENTIA	causes	gene	0.70
AMYLOID	regulates	gene	0.70
ALZHEIMER'S DISEASE	causes	gene	0.70
GENES	therapeutic_target	gene	0.70
APP	regulates	gene	0.70
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Tauopathy	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Stroke	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65

Incoming (472)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	1.00
P60TRP	inhibits	protein	0.80
ALZHEIMER	therapeutic_target	gene	0.80
PSEN2	associated_with	gene	0.70
APP	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
TAU	regulates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
TAU	causes	gene	0.70
ALZHEIMER	causes	gene	0.70
MFN1	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRESENILIN

Understanding Entity Pages

Summary

Wiki Pages (21)

Presenilin-1 (PS1)

calcium-dysregulation-comparison

Alzheimer's Disease Mechanism Index

Mitochondrial Quality Control

DIAN-TU-001 Trial (NCT01760005)

omega-3-fatty-acids-neurodegeneration

Amyloid Cascade Pathway

Protein Aggregation Comparison in Neurodegeneration

PEN2 Gene

mitophagy-defect

APP Flemish Mutation (APP Flemish)

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Amyloid-Beta Aggregation and Plaque Formation

Notch Signaling Pathway in Neurodegeneration

Amyloid-beta Fibril Formation Pathway

er-stress-neurodegeneration

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Calcium Signaling Dysregulation in Neurodegeneration

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

genetics