| Gene Symbol | RORCPROTEIN |
| Protein Type | Receptor |
| Function | is a member of the nuclear receptor superfamily of ligand-dependent transcription factors. |
| Primary Expression | various tissues including liver, adipose tissue, and muscle, while RORγt (isoform 2, also known as RORγt in mice or RORγ2 in humans) is primarily expr |
| Subcellular Localization | signal (NLS) and is a target for post-translational modifications[@moras1999] |
| Molecular Weight | 56 kDa |
| GeneCards | RORCPROTEIN |
| Human Protein Atlas | RORCPROTEIN |
| Hinge Region (D Domain) | Flexible region connecting the DBD to the LBD; contains the nuclear localization signal (NLS) and is a target for post-translational modifications[@moras1999]. |
| C-terminal F Domain | Variable in length and sequence among nuclear receptors; its function in RORγ is less well characterized[@nagy1999]. |
| [Tau](/proteins/tau) pathology | Circadian disruption is common in AD patients, and RORγ dysfunction may contribute to altered circadian gene expression that affects tau phosphorylation and aggregation[@song2020]. |
| Neuroinflammation | RORγ promotes pro-inflammatory cytokine production by microglia and astrocytes. RORγ antagonists reduce neuroinflammation in mouse models of AD, suggesting therapeutic potential[@cunningham2019]. |
| Synaptic plasticity | RORγ regulates genes involved in synaptic function including synapsins, PSD95, and glutamate receptors. RORγ deficiency impairs synaptic plasticity and memory formation[@huang2021]. |
| Cholesterol metabolism | RORγ is sensitive to cholesterol-derived ligands and regulates cholesterol homeostasis in the brain. Dysregulated cholesterol metabolism is implicated in AD pathogenesis[@wang2018]. |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | paeoniflorin |
| Interactions | AHR, Cytokine, CYTOKINES, FOXP3, IL-22, STAT3 |
| KG Connections | 62 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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