| Gene Symbol | SALL1 |
| Aliases | Sal-like protein 1 |
| Chromosome | 16q12.1 |
| Protein Type | Transcription Factor |
| Function | is a zinc-finger transcription factor that plays critical roles in embryonic development and cellular differentiation. |
| Primary Expression | all microglial subpopulations - Maintained in adult microglia throughout life - Not expressed in neurons, astrocytes, or oligodendrocytes - Specific t |
| Subcellular Localization | </strong></td><td>Nucleus</td></tr> |
| Amino Acids | 322 aa |
| Exons | Multiple exons encoding the full-length protein |
| GeneCards | SALL1 |
| Human Protein Atlas | SALL1 |
| Dimerization Domain | SALL1 can form homodimers through its C-terminal region, enabling cooperative DNA binding and transcriptional regulation. |
| Phosphorylation | SALL1 activity is modulated by phosphorylation events that affect its DNA-binding affinity and protein-protein interactions. |
| Sumoylation | Sumoylation of SALL1 influences its transcriptional repressor function and subnuclear localization. |
| Associated Diseases | Alzheimer's disease pathogenesis: |
| Interactions | APOE, CX3CR1, HEXB, P2RY12, TMEM119, TREM2 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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