protein 1,203 words KG: SALL1PROTEIN 2026-04-01
kind:proteinsection:proteinsstate:published
Contents

SALL1 Protein

🔬 Protein Info
Gene SymbolSALL1
AliasesSal-like protein 1
Chromosome16q12.1
Protein TypeTranscription Factor
Functionis a zinc-finger transcription factor that plays critical roles in embryonic development and cellular differentiation.
Primary Expressionall microglial subpopulations - Maintained in adult microglia throughout life - Not expressed in neurons, astrocytes, or oligodendrocytes - Specific t
Subcellular Localization</strong></td><td>Nucleus</td></tr>
Amino Acids322 aa
ExonsMultiple exons encoding the full-length protein
GeneCardsSALL1
Human Protein AtlasSALL1
Associated DiseasesAlzheimer's disease pathogenesis:
InteractionsTMEM119, TREM2, HEXB, APOE, CX3CR1, P2RY12
KG Connections25 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Microglial Purinergic Reprogramming
Score: 0.48

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (15)

BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 6 hypotheses
Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 5 hypotheses
WNK1 Kinase in Neurodegeneration
mechanism · Pages share 5 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 5 hypotheses