gene

HEXB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEXB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

Summary

HEXB is a gene implicated in neurodegeneration research. Key relationships include: inhibits, causes, activates. Associated with Als, Carcinoma, Neurodegeneration. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HEXB
Full Name	Hexosaminidase Subunit Beta
Aliases	Page for HEXB Gene
Chromosome	5q13.3
Function	The beta subunit partners with the alpha subunit (from HEXA) to form hexosaminidase A (Hex A), or pairs with another beta subunit to form hexosaminidase B (Hex B)
Molecular Weight	58.8 kDa
Amino Acids	529 aa
Pathways	MTOR, NF-kB signaling, Oxidative Stress, lipid metabolism
UniProt ID	P07604
NCBI Gene ID	3074
Ensembl ID	ENSG00000213626
OMIM	272800
GeneCards	HEXB
Human Protein Atlas	HEXB
Protein Length	529 amino acids
Associated Diseases	ALS, Sandhoff Disease, disease, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	MTOR, TSC2, Rb, SALL1, TMEM119, LC3
KG Connections	98 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HEXB — AlphaFold P07604 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HEXB["<b>HEXB</b>"]
    neurodegeneration["neurodegeneration"]
    HEXB -->|"causes"| neurodegeneration
    microglial_activation["microglial_activation"]
    HEXB -->|"causes"| microglial_activation
    astrogliosis["astrogliosis"]
    HEXB -->|"causes"| astrogliosis
    Carcinoma{"Carcinoma"}
    HEXB -->|"activates"| Carcinoma
    Oxidative_Stress(["Oxidative Stress"])
    HEXB -->|"activates"| Oxidative_Stress
    HEXB -->|"implicated in"| neurodegeneration
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| HEXB
    LAMP1["LAMP1"]
    LAMP1 -->|"associated with"| HEXB
    TFEB["TFEB"]
    TFEB -->|"activates"| HEXB
    style HEXB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
β-hexosaminidase	associated_with	enzyme	0.95
Β-HEXOSAMINIDASE	encodes	enzyme	0.95
Sandhoff Disease	causes	disease	0.95
Β-Hexosaminidase Activity	regulates	enzyme	0.90
neurodegeneration	causes	phenotype	0.80
microglial_activation	causes	biological_process	0.80
astrogliosis	causes	biological_process	0.80
MTOR	regulates	pathway	0.80
Carcinoma	activates	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	inhibits	disease	0.65
MTOR	inhibits	gene	0.60
GBA	expressed_in	gene	0.60
GLA	expressed_in	gene	0.60
NPC1	expressed_in	gene	0.60
STING	expressed_in	gene	0.60
CTSD	expressed_in	gene	0.60
TSC2	inhibits	gene	0.60
GBA	associated_with	gene	0.60
HEXA	associated_with	gene	0.60
Rb	inhibits	protein	0.60
neurodegeneration	associated_with	disease	0.60
LC3	activates	gene	0.60
LGALS3	activates	gene	0.60
LRP2	activates	gene	0.60
MCOLN1	activates	gene	0.60
SOX9	activates	gene	0.60
SQSTM1	activates	gene	0.60
TFEB	activates	gene	0.60
ULK1	activates	gene	0.60
VIM	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
Mtor	inhibits	pathway	0.60
Sphingolipid	causes	pathway	0.60
DSDNA	inhibits	gene	0.60
AND	expressed_in	gene	0.60
CGAS-STING	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
Innate Immunity	inhibits	pathway	0.60
Cgas-Sting	expressed_in	pathway	0.60
Neuron	inhibits	cell_type	0.60
DEMENTIA	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
Neuron	associated_with	cell_type	0.60

Incoming (30)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
LAMP1	associated_with	gene	0.60
TFEB	activates	gene	0.60
TSC2	inhibits	gene	0.60
CGAS	expressed_in	gene	0.60
MTOR	inhibits	gene	0.60
HEXA	associated_with	gene	0.60
GBA	associated_with	gene	0.60
ACTB	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GUSB	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AND	causes	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	inhibits	gene	0.60
AND	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
AMPK	activates	gene	0.60
GFP	activates	gene	0.60
rapamycin	targets	drug	0.60
GBA	inhibits	gene	0.50
HEXA	co_discussed	gene	0.50
DEMENTIA	inhibits	gene	0.50
GENES	co_discussed	gene	0.50
NEURON	inhibits	gene	0.50
RAPAMYCIN	associated_with	drug	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HEXB

Understanding Entity Pages

Summary

Wiki Pages (21)

HEXB Gene - Hexosaminidase Beta

Microglia Activation Mechanism

Sandhoff Disease

Lipid Dysregulation in Neurodegeneration

Tay-Sachs Disease

TREM2 Microglia Pathway in Alzheimer's Disease

Microglial Dysfunction in Alzheimer's Disease

GBA and Lysosomal Function in Parkinson's Disease

sall1

Primed Microglia

amyloid-responsive-microglia

Disease-Associated Microglia

TFE3 Gene

HEXA Gene - Hexosaminidase Alpha

Hexosaminidase A (Hex A) Protein

Hexosaminidase B (Hex B) Protein

Lipid-Loaded Microglia (Foam Cells)

HEXA (Redirect)

HEXDC3