| Gene Symbol | SMURF1 |
| Aliases | SMURF1PROTEIN |
| Function | SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) is a HECT-type E3 ubiquitin ligase primarily known for its role in regulating TGF-β signaling through degradation of SMAD proteins. |
| Subcellular Localization | </span><span class="infobox-value">Cytoplasm, Plasma membrane, Endosomes</span></div> |
| Pathways | TGF-β signaling, TGF-β |
| GeneCards | SMURF1 |
| Human Protein Atlas | SMURF1 |
| C2 Domain (1-145) | Calcium-dependent membrane association |
| WW Domain 1 (160-193) | PY motif recognition, substrate binding |
| WW Domain 2 (203-236) | PY motif recognition, substrate binding |
| WW Domain 3 (247-280) | PY motif recognition, substrate binding |
| HECT Domain (400-757) | Catalytic domain for ubiquitin transfer |
| TGF-β/BMP signaling | Controls SMAD degradation and pathway activity |
| Actin cytoskeleton | Regulates RHOA degradation and dendritic spine morphology |
| Synaptic plasticity | Modulates AMPA receptor trafficking and spine formation |
| Associated Diseases | Freezing Tolerance |
| Interactions | UVRAG, BECN1, MTOR, LGALS3, CALCINEURIN, PIK3C3 |
| KG Connections | 59 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |