gene

DDIT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDIT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

945Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

DDIT3 (CHOP) is a pro-apoptotic transcription factor mediating ER stress responses; implicated in AD, PD, ALS, and other neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DDIT3
Chromosome	12q24.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	169 aa
Pathways	Akt, Wnt
UniProt ID	P35638
NCBI Gene ID	1649
Ensembl ID	ENSG00000100994
GeneCards	DDIT3
Human Protein Atlas	DDIT3
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, Actin, AKT, AKT1, AKT1S1, ALS
KG Connections	944 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DDIT3 — AlphaFold P35638 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DDIT3 Gene

gene · 899 words

→

CHOP Protein (DDIT3)

protein · 1489 words

→

Pathway Diagram

graph TD
    DDIT3["DDIT3"] -->|"interacts"| Dementia["Dementia"]
    DDIT3["DDIT3"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    DDIT3["DDIT3"] -->|"interacts"| Als["Als"]
    DDIT3["DDIT3"] -->|"interacts"| Alzheimer["Alzheimer"]
    DDIT3["DDIT3"] -->|"interacts"| Parkinson["Parkinson"]
    DDIT3["DDIT3"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| DDIT3["DDIT3"]
    OPTN["OPTN"] -->|"interacts"| DDIT3["DDIT3"]
    DNM1L["DNM1L"] -->|"interacts"| DDIT3["DDIT3"]
    CANX["CANX"] -->|"interacts"| DDIT3["DDIT3"]
    style DDIT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (636)

Target	Relation	Type	Str
DDIT3	encodes	protein	0.00
ATF4	upregulates	gene	0.80
PUMA	upregulates	gene	0.80
HSPA5	upregulates	gene	0.80
Endoplasmic Reticulum Stress	participates_in	process	0.80
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Er Stress	activates	pathway	0.70
ER stress	activates	mechanism	0.70
neural stem cells	regulates	cell_type	0.70
ROS	regulates	gene	0.70
NLR	regulates	gene	0.70
MAPT	inhibits	gene	0.70
neural stem cells	activates	cell_type	0.70
DNA	regulates	gene	0.70
NLR	activates	gene	0.70
DNA	activates	gene	0.70
EIF2AK3	regulates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
ERN1	regulates	gene	0.70
JNK	regulates	gene	0.70
RB1	regulates	gene	0.70
FIP200	regulates	gene	0.70
MAPK signaling	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
OPTN	regulates	gene	0.70
necroptosis	participates_in	pathway	0.70
STING1	regulates	gene	0.70
LC3	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
NBR1	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
Ms	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
ALS	activates	disease	0.65
Tumor	inhibits	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Heart Failure	inhibits	disease	0.65
Cancer	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Glioma	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65

Incoming (309)

Source	Relation	Type	Str
DDIT3	encodes	gene	0.00
H5	inhibits	hypothesis	0.00
DTG	upregulates	drug	0.85
ATF4	activates	gene	0.70
proteostatic_stress	activates	process	0.70
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
OCLN	therapeutic_target	gene	0.60
PPARG	interacts_with	gene	0.60
AMBRA1	activates	entity	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
CYP1A1	activates	gene	0.60
CHOP	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60