protein 785 words KG: SORT1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

SORT1 Protein (Sortilin 1)

🔬 Protein Info
Gene SymbolSORT1
Full NameSortilin 1
Chromosome1p13
Protein FamilyVps10p-domain receptor family
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe central nervous system:
Subcellular LocalizationPlasma membrane, Golgi apparatus, endosomes
Molecular Weight110 kDa
PathwaysMAPK, PI3K pathway
UniProt IDQ99549
NCBI Gene ID602458
Ensembl IDENSG00000134247
OMIM602458
GeneCardsSORT1
Human Protein AtlasSORT1
Associated DiseasesAlzheimer
InteractionsNEK7, ENDOSOMES, RAB7A, IGF2R
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (8)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses