protein 748 words KG: UGCGPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

UGCG Protein (UDP-Glucose Ceramide Glucosyltransferase)

🔬 Protein Info
Gene SymbolUGCG
AliasesUDP-Glucose Ceramide Glucosyltransferase
FunctionThe UGCG gene encodes UDP-glucose ceramide glucosyltransferase (UGCG), also known as glucosylceramide synthase.
Primary Expressionglial cells including astrocytes and oligodendrocytes
Subcellular Localization** | Golgi apparatus |
Molecular Weight46 kDa
PathwaysApoptosis, Nf-Κb, Oxidative Stress, Wnt, apoptosis pathway
Ensembl IDENSG00000165269
GeneCardsUGCG
Human Protein AtlasUGCG
Associated DiseasesAls
InteractionsSTING, RAB5, TSG101, CD63, CD9, RAB35
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.40
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Sphingolipid Metabolism Reprogramming
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in