gene

CD9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

1Analyses

50Outgoing

33Incoming

2Experiments

2Debates

Summary

CD9 (CD9 molecule) - a tetraspanin protein involved in cell adhesion, exosome biology, and membrane organization with relevance to neurodegenerative diseases

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CD9
Aliases	CD9 molecule
Chromosome	12p21.3
Function	encodes a member of the tetraspanin family of membrane proteins, which play crucial roles in cell adhesion, membrane organization, and intercellular communication through exosome formation.
Primary Expression	various cell types within the central nervous system:
Molecular Weight	25 kDa
Amino Acids	228 aa
Exons	8
Pathways	Akt, Epigenetic, Mtor, Pi3K, unfolded protein response
Ensembl ID	ENSG00000010278
GeneCards	CD9
Human Protein Atlas	CD9
Intracellular N- and C-termini	both are short and located in the cytoplasm
Facilitated signal transduction	by bringing together signaling components
Membrane fusion events	particularly relevant for exosome release and cell-cell fusion
Associated Diseases	Aging, Als, Alzheimer, Inflammation, Ms, Neurodegeneration
Interactions	Actin, AGING, AKT, AKT1, ALZHEIMER, AND
KG Connections	131 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD9

gene · 1707 words

→

Pathway Diagram

graph TD
    CD9["CD9"]
    Als{"Als"}
    CD9 -->|"activates"| Als
    Ms{"Ms"}
    CD9 -->|"activates"| Ms
    Hepatitis{"Hepatitis"}
    CD9 -->|"activates"| Hepatitis
    Parkinson{"Parkinson"}
    CD9 -->|"expressed in"| Parkinson
    Dementia{"Dementia"}
    CD9 -->|"expressed in"| Dementia
    ALS{"ALS"}
    CD9 -->|"activates"| ALS
    Epigenetic(["Epigenetic"])
    CD9 -->|"activates"| Epigenetic
    GAIN["GAIN"]
    CD9 -->|"activates"| GAIN
    TREM2["TREM2"]
    CD9 -->|"activates"| TREM2
    PMP22["PMP22"]
    CD9 -->|"expressed in"| PMP22
    MTDNA["MTDNA"]
    CD9 -->|"activates"| MTDNA
    AND["AND"]
    CD9 -->|"activates"| AND
    NASH_diet["NASH diet"]
    NASH_diet -->|"activates"| CD9
    NASH{"NASH"}
    NASH -->|"activates"| CD9
    GAIN -->|"activates"| CD9
    TREM2 -->|"activates"| CD9
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"expressed in"| CD9
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"expressed in"| CD9
    style CD9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (98)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
Hepatitis	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	phosphorylates	disease	0.65
Parkinson	phosphorylates	disease	0.65
Als	phosphorylates	disease	0.65
Aging	phosphorylates	disease	0.65
Neurodegeneration	phosphorylates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Senescence	activates	disease	0.65
unfolded protein response	participates_in	pathway	0.65
INFLAMMATION	associated_with	gene	0.60
Pi3K	activates	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Mtor	activates	pathway	0.60
Akt	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
Monocyte	activates	cell_type	0.60
Actin	interacts_with	protein	0.60
Interleukin	interacts_with	protein	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
GSK3B	phosphorylates	gene	0.60
NEFH	phosphorylates	gene	0.60
MAPT	phosphorylates	gene	0.60
TAU	phosphorylates	gene	0.60
MTDNA	activates	gene	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CDK5	phosphorylates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
RAB35	activates	gene	0.60
UGCG	activates	gene	0.60
RAB5	activates	gene	0.60
astrocytes	expressed_in	cell_type	0.60

Incoming (33)

Source	Relation	Type	Str
NASH diet	activates	phenotype	0.80
NASH	activates	disease	0.64
CD63	biomarker_for	gene	0.60
PI3K	activates	gene	0.60
TAU	associated_with	gene	0.60
CDK5	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
LAMP1	interacts_with	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
AND	activates	gene	0.60
CD81	associated_with	gene	0.60
CD63	expressed_in	gene	0.60
CD81	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
GAIN	activates	gene	0.60
TREM2	activates	gene	0.60
CD63	interacts_with	gene	0.60
CD81	interacts_with	gene	0.60
CD63	activates	gene	0.60
AKT	activates	gene	0.60
AKT1	activates	gene	0.60
CD63	associated_with	gene	0.60
AGING	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
P53	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
SLC3A2	interacts_with	gene	0.60
AXL	activates	gene	0.55
CD81	activates	gene	0.55
APOE	activates	gene	0.55
CD63	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 18 hypotheses Top: 0.814

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Generation and characterization of TIGER mice with inducible CD9-GFP	validation		0.900	0.00	Transgenic TIGER mice	proposed	N/A
Characterization of astrocyte-derived EVs and microglia uptake	exploratory		0.850	0.00	TIGER mice cortical astrocytes	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning CD9 in their description or question text

No additional research found