Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CD9 (CD9 molecule) - a tetraspanin protein involved in cell adhesion, exosome biology, and membrane organization with relevance to neurodegenerative diseases
| Gene Symbol | CD9 |
| Aliases | CD9 molecule |
| Chromosome | 12p21.3 |
| Function | encodes a member of the tetraspanin family of membrane proteins, which play crucial roles in cell adhesion, membrane organization, and intercellular communication through exosome formation. |
| Primary Expression | various cell types within the central nervous system: |
| Molecular Weight | 25 kDa |
| Amino Acids | 228 aa |
| Exons | 8 |
| Pathways | Akt, Epigenetic, Mtor, Pi3K, unfolded protein response |
| Ensembl ID | ENSG00000010278 |
| GeneCards | CD9 |
| Human Protein Atlas | CD9 |
| Intracellular N- and C-termini | both are short and located in the cytoplasm |
| Facilitated signal transduction | by bringing together signaling components |
| Membrane fusion events | particularly relevant for exosome release and cell-cell fusion |
| Associated Diseases | Aging, Als, Alzheimer, Inflammation, Ms, Neurodegeneration |
| Interactions | GAIN, TREM2, AKT1, MTOR, AKT, CD81 |
| KG Connections | 133 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CD9["<b>CD9</b>"]
Als{"Als"}
CD9 -->|"activates"| Als
Ms{"Ms"}
CD9 -->|"activates"| Ms
Hepatitis{"Hepatitis"}
CD9 -->|"activates"| Hepatitis
Parkinson{"Parkinson"}
CD9 -->|"expressed in"| Parkinson
Dementia{"Dementia"}
CD9 -->|"expressed in"| Dementia
ALS{"ALS"}
CD9 -->|"activates"| ALS
Epigenetic(["Epigenetic"])
CD9 -->|"activates"| Epigenetic
GAIN["GAIN"]
CD9 -->|"activates"| GAIN
TREM2["TREM2"]
CD9 -->|"activates"| TREM2
PMP22["PMP22"]
CD9 -->|"expressed in"| PMP22
MTDNA["MTDNA"]
CD9 -->|"activates"| MTDNA
AND["AND"]
CD9 -->|"activates"| AND
NASH_diet["NASH diet"]
NASH_diet -->|"activates"| CD9
NASH{"NASH"}
NASH -->|"activates"| CD9
GAIN -->|"activates"| CD9
TREM2 -->|"activates"| CD9
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"expressed in"| CD9
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
MITOCHONDRIAL_DNA -->|"expressed in"| CD9
style CD9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Hepatitis | activates | disease | 0.65 |
| Parkinson | expressed_in | disease | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | phosphorylates | disease | 0.65 |
| Parkinson | phosphorylates | disease | 0.65 |
| Als | phosphorylates | disease | 0.65 |
| Aging | phosphorylates | disease | 0.65 |
| Neurodegeneration | phosphorylates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| unfolded protein response | participates_in | pathway | 0.65 |
| GAIN | activates | gene | 0.60 |
| TREM2 | activates | gene | 0.60 |
| PMP22 | expressed_in | gene | 0.60 |
| GSK3B | associated_with | gene | 0.60 |
| AKT1 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| CD81 | interacts_with | gene | 0.60 |
| CD63 | interacts_with | gene | 0.60 |
| CDK5 | phosphorylates | gene | 0.60 |
| GSK3B | phosphorylates | gene | 0.60 |
| NEFH | phosphorylates | gene | 0.60 |
| MAPT | phosphorylates | gene | 0.60 |
| TAU | phosphorylates | gene | 0.60 |
| CD81 | associated_with | gene | 0.60 |
| GLS | associated_with | gene | 0.60 |
| L1CAM | associated_with | gene | 0.60 |
| RAB35 | activates | gene | 0.60 |
| UGCG | activates | gene | 0.60 |
| RAB5 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| L1CAM | biomarker_for | gene | 0.60 |
| MOG | biomarker_for | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| MTDNA | activates | gene | 0.60 |
| EXOSOMES | interacts_with | gene | 0.60 |
| ENDOSOMES | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NASH diet | activates | phenotype | 0.80 |
| NASH | activates | disease | 0.64 |
| GAIN | activates | gene | 0.60 |
| TREM2 | activates | gene | 0.60 |
| LAMP1 | interacts_with | gene | 0.60 |
| CD63 | biomarker_for | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| CDK5 | associated_with | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| NEFH | associated_with | gene | 0.60 |
| CD63 | interacts_with | gene | 0.60 |
| CD81 | interacts_with | gene | 0.60 |
| CD63 | associated_with | gene | 0.60 |
| CD63 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| AKT1 | activates | gene | 0.60 |
| CD81 | associated_with | gene | 0.60 |
| CD63 | expressed_in | gene | 0.60 |
| CD81 | expressed_in | gene | 0.60 |
| PARKINSON'S DISEASE | expressed_in | gene | 0.60 |
| MITOCHONDRIAL DNA | expressed_in | gene | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| SLC3A2 | interacts_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| APOE | activates | gene | 0.55 |
| AXL | activates | gene | 0.55 |
| CD81 | activates | gene | 0.55 |
| CD63 | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||