gene

CD9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections
0Hypotheses
0Analyses
50Outgoing
34Incoming

Summary

CD9 (CD9 molecule) - a tetraspanin protein involved in cell adhesion, exosome biology, and membrane organization with relevance to neurodegenerative diseases

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🧬 Gene Info
Gene SymbolCD9
AliasesCD9 molecule
Chromosome12p21.3
Functionencodes a member of the tetraspanin family of membrane proteins, which play crucial roles in cell adhesion, membrane organization, and intercellular communication through exosome formation.
Primary Expressionvarious cell types within the central nervous system:
Molecular Weight25 kDa
Amino Acids228 aa
Exons8
PathwaysAkt, Epigenetic, Mtor, Pi3K, unfolded protein response
Ensembl IDENSG00000010278
GeneCardsCD9
Human Protein AtlasCD9
Intracellular N- and C-terminiboth are short and located in the cytoplasm
Facilitated signal transductionby bringing together signaling components
Membrane fusion eventsparticularly relevant for exosome release and cell-cell fusion
Associated DiseasesAging, Als, Alzheimer, Inflammation, Ms, Neurodegeneration
InteractionsGAIN, TREM2, AKT1, MTOR, AKT, CD81
KG Connections133 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CD9

gene · 1707 words

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

mechanism · 4859 words

Liquid Biopsy Diagnostics for Corticobasal Syndrome

biomarker · 3975 words

Liquid Biopsy Diagnostics for Corticobasal Syndrome

biomarker · 3975 words

Exosome and Extracellular Vesicle Brain Delivery

therapeutic · 3732 words

Cell-to-cell transmission of alpha-synuclein

general · 3488 words

Pathway Diagram

graph TD
    CD9["<b>CD9</b>"]
    Als{"Als"}
    CD9 -->|"activates"| Als
    Ms{"Ms"}
    CD9 -->|"activates"| Ms
    Hepatitis{"Hepatitis"}
    CD9 -->|"activates"| Hepatitis
    Parkinson{"Parkinson"}
    CD9 -->|"expressed in"| Parkinson
    Dementia{"Dementia"}
    CD9 -->|"expressed in"| Dementia
    ALS{"ALS"}
    CD9 -->|"activates"| ALS
    Epigenetic(["Epigenetic"])
    CD9 -->|"activates"| Epigenetic
    GAIN["GAIN"]
    CD9 -->|"activates"| GAIN
    TREM2["TREM2"]
    CD9 -->|"activates"| TREM2
    PMP22["PMP22"]
    CD9 -->|"expressed in"| PMP22
    MTDNA["MTDNA"]
    CD9 -->|"activates"| MTDNA
    AND["AND"]
    CD9 -->|"activates"| AND
    NASH_diet["NASH diet"]
    NASH_diet -->|"activates"| CD9
    NASH{"NASH"}
    NASH -->|"activates"| CD9
    GAIN -->|"activates"| CD9
    TREM2 -->|"activates"| CD9
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"expressed in"| CD9
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"expressed in"| CD9
    style CD9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (99)

TargetRelationTypeStr
Alsactivatesdisease0.65
Msactivatesdisease0.65
Hepatitisactivatesdisease0.65
Parkinsonexpressed_indisease0.65
Dementiaexpressed_indisease0.65

Incoming (34)

SourceRelationTypeStr
NASH dietactivatesphenotype0.80
NASHactivatesdisease0.64
GAINactivatesgene0.60
TREM2activatesgene0.60
LAMP1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found