gene

CD63

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD63: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

Summary

CD63 (LAMP-3) is a tetraspanin protein involved in lysosomal function, exosome formation, and neurodegenerative diseases including Parkinson's and Alzheimer's.

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🧬 Gene Info

Gene Symbol	CD63
Aliases	LAMP-3
Chromosome	12q13.2
Function	is a member of the tetraspanin superfamily that plays crucial roles in membrane trafficking, lysosomal function, and exosome biogenesis.
Primary Expression	intracellular vesicles, including lysosomes, endosomes, and secretory granules[@matila1995][@tomlinson1999]
Subcellular Localization	CD63 primarily localizes to lysosomes (primary storage compartment), late endosomes (multivesicular body formation), sec
Amino Acids	238 aa
Exons	7
Pathways	oxidative stress response, phagocytosis, unfolded protein response
Ensembl ID	ENSG00000135404
GeneCards	CD63
Human Protein Atlas	CD63
Associated Diseases	Als
Interactions	CD4, CD81, CD9, RAB35, UGCG, RAB5
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD63["<b>CD63</b>"]
    FERRITINH["FERRITINH"]
    CD63 -->|"associated with"| FERRITINH
    Cholesterol(["Cholesterol"])
    CD63 -->|"interacts with"| Cholesterol
    neurodegeneration["neurodegeneration"]
    CD63 -->|"implicated in"| neurodegeneration
    EXOSOMES["EXOSOMES"]
    EXOSOMES -->|"interacts with"| CD63
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"associated with"| CD63
    NPC1["NPC1"]
    NPC1 -->|"interacts with"| CD63
    style CD63 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
limbal stem cells	expressed_in	cell_type	0.90
corneal epithelial homeostasis	contributes_to	process	0.90
PAX6	regulates	gene	0.85
cell proliferation	promotes	process	0.85
KRT12	upregulates	gene	0.85
FERRITINH	associated_with	protein	0.80
ALDH1A1	upregulates	gene	0.80
CLU	upregulates	gene	0.80
corneal epithelium	therapeutic_target	cell_type	0.75
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
CD81	expressed_in	gene	0.60
CD4	inhibits	gene	0.60
CD9	biomarker_for	gene	0.60
CD9	interacts_with	gene	0.60
CD9	associated_with	gene	0.60
CD81	associated_with	gene	0.60
GLS	associated_with	gene	0.60
L1CAM	associated_with	gene	0.60
CD9	activates	gene	0.60
RAB35	activates	gene	0.60
UGCG	activates	gene	0.60
RAB5	activates	gene	0.60
TAU	interacts_with	gene	0.60
AQP4	interacts_with	gene	0.60
CLU	expressed_in	gene	0.60
KRT12	expressed_in	gene	0.60
TGFBI	expressed_in	gene	0.60
DCX	activates	gene	0.60
CD9	expressed_in	gene	0.60
Cholesterol	interacts_with	pathway	0.60
INFLAMMATION	inhibits	gene	0.60
GENES	inhibits	gene	0.60
MICRORNAS	inhibits	gene	0.60
EXOSOMES	inhibits	gene	0.60
Microrna	inhibits	pathway	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	biomarker_for	gene	0.60
T Cell	interacts_with	cell_type	0.60
Actin	interacts_with	protein	0.60
Interleukin	interacts_with	protein	0.60
Fus	interacts_with	protein	0.60
App	interacts_with	protein	0.60
ASTROCYTES	therapeutic_target	gene	0.60

Incoming (20)

Source	Relation	Type	Str
NPC1	interacts_with	gene	0.60
FOXP3	inhibits	gene	0.60
LAMP1	interacts_with	gene	0.60
CD9	interacts_with	gene	0.60
CD81	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
ABCB5	biomarker_for	gene	0.60
ALDH1A1	expressed_in	gene	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	associated_with	gene	0.60
MIRNAS	inhibits	gene	0.60
AND	associated_with	gene	0.60
GENES	regulates	gene	0.60
AND	biomarker_for	gene	0.60
SLC3A2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
APOE	activates	gene	0.55
APOE	debate_co_mention	gene	0.45
autophagy	debate_co_mention	pathway	0.45
BMAL1	debate_co_mention	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD63

Understanding Entity Pages

Summary

Wiki Pages (21)

CD63

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Exosome and Extracellular Vesicle Brain Delivery

bbb-transport-mechanisms

Cell-to-cell transmission of alpha-synuclein

Extracellular Vesicles in Neurodegeneration

Exosome Biogenesis in Neurodegeneration

Extracellular Vesicle-Mediated Synuclein Propagation Hypothesis in Parkinson's Disease

Exosome-Mediated Pathological Protein Propagation

Tau Propagation and Seeding in Progressive Supranuclear Palsy

CD81

Validate Mitochondria-Lysosome Contact Site Dysfunction in PD

Engineered Exosomes for Intranasal CNS Delivery

Alpha-Synuclein Exosomal Secretion

Exosome-Based Therapeutics for Neurodegenerative Diseases

Lysosomal-Impaired Neurons

endosomal-lysosomal-cbs

Astrocyte-Derived Exosomal mRNA Reference Genes for Alzheimer's Disease

CD9

Exosomes

Exosome-Secreting Neurons

Pathway Diagram

Outgoing (83)

Incoming (20)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)