gene

RAB35

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

0Analyses

35Outgoing

15Incoming

Summary

RAB35 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Alzheimer, Ftd, Ms. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB35
Full Name	Ras-Related Protein Rab-35
Aliases	Ras-Associated Protein 35
Chromosome	12q24.31
Function	is a member of the Rab GTPase family that plays critical roles in regulating actin dynamics, endocytic trafficking, and synaptic vesicle recycling at presynaptic terminals.
Primary Expression	the brain, particularly in: - Hippocampus: Highest expression in CA1-CA3 regions and dentate gyrus - Cerebral cortex: Layer 2-4 pyramidal neur
Subcellular Localization	presynaptic terminals where it plays a central role in synaptic vesicle endocytosis and recycling. Following neurotransm
Pathways	Vesicle Cargo Routing, Vesicle Transport
UniProt ID	Q8WVM8
NCBI Gene ID	11020
Ensembl ID	ENSG00000131721
OMIM	607352
GeneCards	RAB35
Human Protein Atlas	RAB35
Protein Name	Ras-related protein Rab-35
Associated Diseases	Als, Alzheimer, Ftd, Tauopathy
Interactions	UGCG, RAB5, TAUOPATHY, TAU PATHOLOGY, ALZHEIMER'S DISEASE, ALZHEIMER
KG Connections	50 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB35 — AlphaFold Q8WVM8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAB35["<b>RAB35</b>"]
    Alzheimer{"Alzheimer"}
    RAB35 -->|"activates"| Alzheimer
    Ms{"Ms"}
    RAB35 -->|"activates"| Ms
    Tauopathy{"Tauopathy"}
    RAB35 -->|"activates"| Tauopathy
    RAB35 -->|"associated with"| Alzheimer
    Ftd{"Ftd"}
    RAB35 -->|"associated with"| Ftd
    RAB35 -->|"associated with"| Tauopathy
    CHMP6["CHMP6"]
    RAB35 -->|"regulates"| CHMP6
    RAB7A["RAB7A"]
    RAB35 -->|"regulates"| RAB7A
    TAU["TAU"]
    RAB35 -->|"regulates"| TAU
    TAUOPATHY["TAUOPATHY"]
    RAB35 -->|"activates"| TAUOPATHY
    ENDOSOME["ENDOSOME"]
    RAB35 -->|"regulates"| ENDOSOME
    LYSOSOME["LYSOSOME"]
    RAB35 -->|"regulates"| LYSOSOME
    RAB7A -->|"regulates"| RAB35
    CHMP6 -->|"regulates"| RAB35
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| RAB35
    LYSOSOME -->|"regulates"| RAB35
    ENDOSOME -->|"regulates"| RAB35
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| RAB35
    TAU_PATHOLOGY["TAU PATHOLOGY"]
    TAU_PATHOLOGY -->|"activates"| RAB35
    AND["AND"]
    AND -->|"regulates"| RAB35
    style RAB35 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

Target	Relation	Type	Str
Vesicle Cargo Routing	regulates	process	0.80
Vesicle Transport	regulates	process	0.80
MAPT	regulates	protein	0.70
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Tauopathy	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Tauopathy	associated_with	disease	0.65
Tauopathy	stabilizes	disease	0.65
Alzheimer	stabilizes	disease	0.65
Als	associated_with	disease	0.65
CHMP6	regulates	gene	0.60
RAB7A	regulates	gene	0.60
TAU	regulates	gene	0.60
UGCG	activates	gene	0.60
RAB5	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
ENDOSOME	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TSG101	regulates	gene	0.60
TAUOPATHY	stabilizes	gene	0.60
Actin	stabilizes	protein	0.60
Tau Protein	stabilizes	protein	0.60
Raf	regulates	protein	0.60
Actin	activates	protein	0.60
TSG101	activates	gene	0.60
EXOSOMES	associated_with	gene	0.60
Epithelial	associated_with	cell_type	0.60
LYSOSOME	interacts_with	gene	0.50
ENDOSOME	interacts_with	concept	0.50

Incoming (15)

Source	Relation	Type	Str
RAB7A	regulates	gene	0.60
CHMP6	regulates	gene	0.60
TAU	regulates	gene	0.60
CD63	activates	gene	0.60
CD9	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
LYSOSOME	regulates	gene	0.60
ENDOSOME	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
TSG101	regulates	gene	0.60
ALZHEIMER	stabilizes	gene	0.60
TAUOPATHY	activates	gene	0.60
CHMP6	interacts_with	gene	0.50
RAB7A	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RAB35

Understanding Entity Pages

Summary

Wiki Pages (21)

RAB35 — Ras-Associated Protein 35

Synaptic Vesicle Trafficking in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

LRRK2 G2019S

Lysosomal Dysfunction in Neurodegeneration

autophagy-lysosome-dysfunction

Endolysosomal Trafficking Defects in Neurodegeneration

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study t... (NCT05348785)

LRRK2-GBA Combination Therapy for Parkinson's Disease

Progressive Supranuclear Palsy Treatment Landscape

LRRK2 Kinase-Targeting Therapies

LRRK2 Kinase Pathway in Parkinson's Disease

LRRK2 Pathway in PD

LRRK2 Signaling Pathway in Parkinson's Disease

GDI2 Gene

lrrk2-protein